Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors

Blood tissue Plasminogen Activator (tPA) of liver origin contributes to neurovascular coupling involving brain endothelial N-Methyl-D-Aspartate (NMDA) receptors

Abstract Background Regulation of cerebral blood flow (CBF) directly influence brain functions and dysfunctions and involves complex mechanisms, including neurovascular coupling (NVC). It was suggested that the serine protease tissue-type plasminogen activator (tPA) could control CNV induced by whis...

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Bibliographic Details
Main Authors: Jonathane Furon, Mervé Yetim, Elsa Pouettre, Sara Martinez de Lizarrondo, Eric Maubert, Yannick Hommet, Laurent Lebouvier, Ze Zheng, Carine Ali, Denis Vivien
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Fluids and Barriers of the CNS
Subjects:
NVC
tPA
NMDAR
GluN1
Liver
Online Access:https://doi.org/10.1186/s12987-023-00411-w

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