The IGF–PAPP-A–Stanniocalcin Axis in Serum and Ascites Associates with Prognosis in Patients with Ovarian Cancer

The IGF–PAPP-A–Stanniocalcin Axis in Serum and Ascites Associates with Prognosis in Patients with Ovarian Cancer

Pregnancy-associated plasma protein-A (PAPP-A) and PAPP-A2 modulate insulin-like growth factor (IGF) action and are inhibited by the stanniocalcins (STC1 and STC2). We previously demonstrated increased PAPP-A and IGF activity in ascites from women with ovarian carcinomas. In this prospective, longit...

Full description

Bibliographic Details
Main Authors:	Rikke Hjortebjerg, Claus Høgdall, Kristian Horsman Hansen, Estrid Høgdall, Jan Frystyk
Format:	Article
Language:	English
Published:	MDPI AG 2024-02-01
Series:	International Journal of Molecular Sciences
Subjects:	ascites insulin-like growth factor insulin-like growth factor binding protein mortality ovarian cancer pregnancy-associated plasma protein-A
Online Access:	https://www.mdpi.com/1422-0067/25/4/2014

Similar Items

Pregnancy-Associated Plasma Protein-A2 Is Associated With Mortality in Patients With Lung Cancer
by: Rikke Hjortebjerg, et al.
Published: (2020-09-01)

IGF-Binding Proteins: Why Do They Exist and Why Are There So Many?
by: John B. Allard, et al.
Published: (2018-04-01)

Associations among IGF-1, IGF2, IGF-1R, IGF-2R, IGFBP-3, insulin genetic polymorphisms and central precocious puberty in girls
by: Hua-Pin Chang, et al.
Published: (2018-09-01)

IGF-I and IGFBP-3 serum levels in patients hospitalized for complications of liver cirrhosis
by: Marcelo Fernando Ronsoni, et al.
Published: (2013-05-01)

The Influence of Gestational Diabetes Mellitus upon the Selected Parameters of the Maternal and Fetal System of Insulin-Like Growth Factors (IGF-1, IGF-2, IGFBP1-3)—A Review and a Clinical Study
by: Tomasz Gęca, et al.
Published: (2020-10-01)

Animal insulin-like growth factor binding proteins and their biological functions
by: Z. Kostecká, et al.
Published: (2002-02-01)

Protein Plasma Levels of the IGF Signalling System Are Altered in Major Depressive Disorder
by: Carlos Fernández-Pereira, et al.
Published: (2023-10-01)

Effects of 8 Weeks of Resistance Training and IGF-1 Injection on Biochemical Markers of Cancer and Colorectal Structures in Rats
by: Babisan Askari, et al.
Published: (2017-11-01)

Insulin-like Growth Factor Binding Protein 3 Increases Mouse Preimplantation Embryo Cleavage Rate by Activation of IGF1R and EGFR Independent of IGF1 Signalling
by: Charmaine J. Green, et al.
Published: (2022-11-01)

Daily Rhythms in the IGF-1 System in the Liver of Goldfish and Their Synchronization to Light/Dark Cycle and Feeding Time
by: Aitana Alonso-Gómez, et al.
Published: (2022-11-01)

Cord blood level of insulin-like growth factor-1 and IGF binding protein-3 in monochorionic twins
by: Ru-Jeng Teng, et al.
Published: (2015-04-01)

Correlation of Insulin Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein with LH, FSH and Testosterone in Iraqi Children with Growth Hormone Deficiency
by: Athraa F. Hasan, et al.
Published: (2023-03-01)

Insulin-like growth factors: Ligands, binding proteins, and receptors
by: Derek LeRoith, et al.
Published: (2021-10-01)

Cardiovascular disease risk markers in children under 10 years of age and their relationship with serum concentrations of IGF-1, IGFBP-1, IGFBP-2 and IGFBP-3
by: Sorany Vera, et al.
Published: (2020-01-01)

Serum IGF-1 in patients with rheumatoid arthritis: correlation with disease activity
by: Hanna Lee, et al.
Published: (2022-04-01)

Role of Tumor and Stroma-Derived IGF/IGFBPs in Pancreatic Cancer
by: Divya Thomas, et al.
Published: (2020-05-01)

Cloning and expression of full-length human insulin-like growth factor binding protein 3 (IGFBP3) in the Escherichia coli
by: Emad Khodadadi, et al.
Published: (2015-01-01)

Somatotropic Axis Regulation Unravels the Differential Effects of Nutritional and Environmental Factors in Growth Performance of Marine Farmed Fishes
by: Jaume Pérez-Sánchez, et al.
Published: (2018-11-01)

Serum Insulin-Like Growth Factor Axis and the Risk of Pancreatic Cancer: Systematic Review and Meta-Analysis
by: Yuanfeng Gong, et al.
Published: (2017-04-01)

CA 19-9 but Not IGF-1/IGFBP-2 Is a Useful Biomarker for Pancreatic Ductal Adenocarcinoma (PDAC) and Chronic Pancreatitis (CP) Differentiation
by: Barbara Wlodarczyk, et al.
Published: (2023-06-01)

The IGF system in patients with inflammatory bowel disease treated with prednisolone or infliximab: potential role of the stanniocalcin-2 / PAPP-A / IGFBP-4 axis
by: Rikke Hjortebjerg, et al.
Published: (2019-06-01)

Insulin Like Growth Factor Binding Protein 7 as a Novel Diagnostic Marker in Sera of Iraqi Patients with Acromegaly
by: Layla Othman Farhan, et al.
Published: (2023-06-01)

The Roles of the IGF Axis in the Regulation of the Metabolism: Interaction and Difference between Insulin Receptor Signaling and IGF-I Receptor Signaling
by: Tomoko Okuyama, et al.
Published: (2021-06-01)

LIF–IGF Axis Contributes to the Proliferation of Neural Progenitor Cells in Developing Rat Cerebrum
by: Sho Takata, et al.
Published: (2022-10-01)

Nutritional condition and IGF-1 and IGFBP-2 serum concentrations in students aged 7 to 9 attending two educational institutions
by: Jenifer Tatiana Figueroa, et al.
Published: (2016-07-01)

Serum IGF-1 and IGFBP-3 Levels in Middle Aged Turkish Males: Relationships with Bone Mineral Density and Markers of Bone Turnover (Male Osteoporosis & IGF-1, IGFBP-3) - Original Investigation
by: Melek Sezgin, et al.
Published: (2007-06-01)

Do insulin-like growth factor associated proteins qualify as a tumor marker? results of a prospective study in 163 cancer patients*
by: Matuschek G, et al.
Published: (2011-10-01)

IGF-I and IGFBP-3 levels and their correlations with carcinoembryonic antigen in colorectal cancer patients
by: Çiğdem Yağcıoğlu Yücel, et al.
Published: (2018-03-01)

Estudio inmunocitoquímico y molecular de cultivo primario de tejido molar
by: Yinth Andrea Bernal, et al.
Published: (2006-12-01)

Insulin-Like Growth Factor-2 Is Induced Following 5-Aminolevulinic Acid-Mediated Photodynamic Therapy in SW620 Human Colon Cancer Cell Line
by: Marta Woźniak, et al.
Published: (2015-10-01)

Niveles séricos de los factores de crecimiento similares a la insulina I y II y su proteína 3 de enlace en mujeres con lesiones escamosas intraepiteliales y cáncer de cuello uterino
by: Martha Lucía Serrano, et al.
Published: (2006-06-01)

Associations of serum carotenoid concentrations and fruit or vegetable consumption with serum insulin-like growth factor (IGF)-1 and IGF binding protein-3 concentrations in the Third National Health and Nutrition Examination Survey (NHANES III)
by: Anja Diener, et al.
Published: (2016-01-01)

Evaluation of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-3 Expression Levels in Patients with Chronic Lymphocytic Leukemia
by: Mesut Ayer, et al.
Published: (2016-11-01)

Insulin-Like Growth Factor Axis Biomarkers and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis
by: Xi-Rui Wang, et al.
Published: (2019-07-01)

Free Insulin-like Growth Factor (IGF)-I in Children with PWS
by: Layla Damen, et al.
Published: (2022-02-01)

The Interaction of Insulin-Like Growth Factor Binding Protein 3 (IGFBP-3) in Insulin-Like Growth Factor (IGF)-Independent System
by: Amir Ansari, et al.
Published: (2017-12-01)

IGF-1 Stimulates Glycolytic ATP Production in MCF-7L Cells
by: Bhumika Rajoria, et al.
Published: (2023-06-01)

Elevated C-peptide and insulin predict increased risk of colorectal adenomas in normal mucosa
by: Vidal Adriana C, et al.
Published: (2012-09-01)

Insulin-like growth factor 1 and insulin-like growth factor binding protein-3 as predictive biomarkers of depression and migraine in obese women
by: Nearmeen M Rashad, et al.
Published: (2019-01-01)

Molecular Characterization and Expression Analysis of Insulin-like Growth Factor-1 and Insulin-like Growth Factor Binding Protein-1 Genes in Qinghai-Tibet Plateau and Lowland
by: Ya-bing Chen, et al.
Published: (2015-01-01)