Anxiety and Alzheimer’s disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

Anxiety and Alzheimer’s disease pathogenesis: focus on 5-HT and CRF systems in 3xTg-AD and TgF344-AD animal models

Dementia remains one of the leading causes of morbidity and mortality in older adults. Alzheimer’s disease (AD) is the most common type of dementia, affecting over 55 million people worldwide. AD is characterized by distinct neurobiological changes, including amyloid-beta protein deposits and tau ne...

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Bibliographic Details
Main Authors: Nicole C. Reyna, Benjamin J. Clark, Derek A. Hamilton, Nathan S. Pentkowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer’s disease
corticotropin releasing factor
serotonin
stress
HPA Axis
Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2023.1251075/full

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