Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration
Abstract Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. Existing clinical treatment methods cannot fully achieve periodontal tissue regeneration; thus, due to the unique characteristics of me...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-02-01
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| Series: | Stem Cell Research & Therapy |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13287-023-03242-6 |
| _version_ | 1827985078324559872 |
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| author | Liangrui Chen Shasha Zhu Shujuan Guo Weidong Tian |
| author_facet | Liangrui Chen Shasha Zhu Shujuan Guo Weidong Tian |
| author_sort | Liangrui Chen |
| collection | DOAJ |
| description | Abstract Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. Existing clinical treatment methods cannot fully achieve periodontal tissue regeneration; thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. Accumulating evidence supports the view that the role of MSCs in regenerative medicine is mainly achieved by the paracrine pathway rather than direct proliferation and differentiation at the injured site. Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. As a cell-free therapy, MSCs-derived extracellular vesicles (MSC-EVs) have some preponderance on stability, immune rejection, ethical supervision, and other problems; therefore, they may have a broad clinical application prospect. Herein, we gave a brief introduction to MSC-EVs and focused on their mechanisms and clinical application in periodontal regeneration. |
| first_indexed | 2024-04-09T23:07:57Z |
| format | Article |
| id | doaj.art-e4e7cc9943094269a720177e257874a9 |
| institution | Directory Open Access Journal |
| issn | 1757-6512 |
| language | English |
| last_indexed | 2024-04-09T23:07:57Z |
| publishDate | 2023-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Stem Cell Research & Therapy |
| spelling | doaj.art-e4e7cc9943094269a720177e257874a92023-03-22T10:34:58ZengBMCStem Cell Research & Therapy1757-65122023-02-0114111310.1186/s13287-023-03242-6Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regenerationLiangrui Chen0Shasha Zhu1Shujuan Guo2Weidong Tian3State Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan UniversityState Key Laboratory of Oral Disease & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Oral Regenerative Medicine, West China School of Stomatology, Sichuan UniversityAbstract Periodontitis is a high prevalence oral disease which damages both the hard and soft tissue of the periodontium, resulting in tooth mobility and even loss. Existing clinical treatment methods cannot fully achieve periodontal tissue regeneration; thus, due to the unique characteristics of mesenchymal stem cells (MSCs), they have become the focus of attention and may be the most promising new therapy for periodontitis. Accumulating evidence supports the view that the role of MSCs in regenerative medicine is mainly achieved by the paracrine pathway rather than direct proliferation and differentiation at the injured site. Various cells release lipid-enclosed particles known as extracellular vesicles (EVs), which are rich in bioactive substances. In periodontitis, EVs play a pivotal role in regulating the biological functions of both periodontal tissue cells and immune cells, as well as the local microenvironment, thereby promoting periodontal injury repair and tissue regeneration. As a cell-free therapy, MSCs-derived extracellular vesicles (MSC-EVs) have some preponderance on stability, immune rejection, ethical supervision, and other problems; therefore, they may have a broad clinical application prospect. Herein, we gave a brief introduction to MSC-EVs and focused on their mechanisms and clinical application in periodontal regeneration.https://doi.org/10.1186/s13287-023-03242-6PeriodontitisExtracellular vesiclesMesenchymal stem cellsPeriodontal regeneration |
| spellingShingle | Liangrui Chen Shasha Zhu Shujuan Guo Weidong Tian Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration Stem Cell Research & Therapy Periodontitis Extracellular vesicles Mesenchymal stem cells Periodontal regeneration |
| title | Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration |
| title_full | Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration |
| title_fullStr | Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration |
| title_full_unstemmed | Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration |
| title_short | Mechanisms and clinical application potential of mesenchymal stem cells-derived extracellular vesicles in periodontal regeneration |
| title_sort | mechanisms and clinical application potential of mesenchymal stem cells derived extracellular vesicles in periodontal regeneration |
| topic | Periodontitis Extracellular vesicles Mesenchymal stem cells Periodontal regeneration |
| url | https://doi.org/10.1186/s13287-023-03242-6 |
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