Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors
Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pitu...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2018-07-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fendo.2018.00391/full |
| _version_ | 1819209274626146304 |
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| author | Anca Zimmermann Rüdiger Zwerenz Michael Droste Christof Schöfl Christian J. Strasburger Ursula Plöckinger Athanasia Ziagaki Jürgen Honegger Anne Dixius Bledar Millaku Gerrit Toenges Manfred E. Beutel Matthias M. Weber |
| author_facet | Anca Zimmermann Rüdiger Zwerenz Michael Droste Christof Schöfl Christian J. Strasburger Ursula Plöckinger Athanasia Ziagaki Jürgen Honegger Anne Dixius Bledar Millaku Gerrit Toenges Manfred E. Beutel Matthias M. Weber |
| author_sort | Anca Zimmermann |
| collection | DOAJ |
| description | Objective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities.Design: Cross sectional, multicentric.Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent. Age, sex, IGF-1 concentrations, comorbidities, treatment modalities and pituitary insufficiency were documented.Results: Acromegalic patients or specific patient-subgroups were more agreeable, neurotic, exploitable/permissive, introverted/socially avoidant, non-assertive/insecure, nurturant and less open to experience, cold/denying, domineering, compared to normal values from the healthy population (controls). Multivariable analysis demonstrated that these overall results were due to the specific patient subgroups as patients on chronic medication, with arthrosis and pituitary insufficiency. Disease activity was only associated with the trait nurturant. Higher scores for introversion were associated with arthrosis. Lower domineering was independent of any disease- or treatment related variable or comorbidity. The GBB inventory showed overall higher scores in patients, with higher scores for exhaustion and general complaints being associated with pituitary insufficiency, coronary heart disease and history of malignancy in the multivariable analysis. Joint complaints were independent of any disease- or treatment- related variable.Conclusions: We define new aspects of a distinct neuropsychological profile in patients with acromegaly, which are largely independent of disease activity. Chronic physical complaints are more pronounced in patients than in controls, with exhaustion and general complaints showing no association with disease activity. |
| first_indexed | 2024-12-23T05:52:41Z |
| format | Article |
| id | doaj.art-e4ea5d3d42284b01a7e606dacc775a83 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-12-23T05:52:41Z |
| publishDate | 2018-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-e4ea5d3d42284b01a7e606dacc775a832022-12-21T17:57:54ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922018-07-01910.3389/fendo.2018.00391385259Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing FactorsAnca Zimmermann0Rüdiger Zwerenz1Michael Droste2Christof Schöfl3Christian J. Strasburger4Ursula Plöckinger5Athanasia Ziagaki6Jürgen Honegger7Anne Dixius8Bledar Millaku9Gerrit Toenges10Manfred E. Beutel11Matthias M. Weber12Department of Endocrinology and Metabolic Diseases, 1. Medical Clinic, University Medical Center, Mainz, GermanyClinic and Polyclinic for Psychosomatic Medicine and Psychotherapy, University Medical Center, Mainz, GermanyEndocrinology and Diabetology Praxis, Oldenburg, GermanyCenter of Endocrinology and Metabolism, Bamberg, GermanyClinical Endocrinology, Charité Universitätsmedizin Berlin, Berlin, GermanyInterdisciplinary Center of Metabolism: Endocrinology, Diabetes and Metabolism, Charité Universitätsmedizin Berlin, Berlin, GermanyInterdisciplinary Center of Metabolism: Endocrinology, Diabetes and Metabolism, Charité Universitätsmedizin Berlin, Berlin, GermanyNeurosurgery Clinic, University of Tübingen, Tübingen, GermanyDepartment of Endocrinology and Metabolic Diseases, 1. Medical Clinic, University Medical Center, Mainz, GermanyDepartment of Endocrinology and Metabolic Diseases, 1. Medical Clinic, University Medical Center, Mainz, GermanyInstitute of Medical Biostatistics, Epidemiology and Informatics, University of Mainz, Mainz, GermanyClinic and Polyclinic for Psychosomatic Medicine and Psychotherapy, University Medical Center, Mainz, GermanyDepartment of Endocrinology and Metabolic Diseases, 1. Medical Clinic, University Medical Center, Mainz, GermanyObjective: Acromegalic patients display a distinct neuropsychological profile and suffer from chronic physical complaints. We aimed to investigate in more detail these aspects in acromegalic patients, dependent on influencing factors like disease activity, age, sex, chronic medication, surgery, pituitary radiation, pituitary insufficiency and comorbidities.Design: Cross sectional, multicentric.Methods: 129 patients (M/W 65/64, 58.3 ± 12.7 years, 53/76 with active/controlled disease). Acromegalic patients completed the following inventories: NEO-FFI, IIP-D, and the Giessen Complaints List (GBB-24), after written informed consent. Age, sex, IGF-1 concentrations, comorbidities, treatment modalities and pituitary insufficiency were documented.Results: Acromegalic patients or specific patient-subgroups were more agreeable, neurotic, exploitable/permissive, introverted/socially avoidant, non-assertive/insecure, nurturant and less open to experience, cold/denying, domineering, compared to normal values from the healthy population (controls). Multivariable analysis demonstrated that these overall results were due to the specific patient subgroups as patients on chronic medication, with arthrosis and pituitary insufficiency. Disease activity was only associated with the trait nurturant. Higher scores for introversion were associated with arthrosis. Lower domineering was independent of any disease- or treatment related variable or comorbidity. The GBB inventory showed overall higher scores in patients, with higher scores for exhaustion and general complaints being associated with pituitary insufficiency, coronary heart disease and history of malignancy in the multivariable analysis. Joint complaints were independent of any disease- or treatment- related variable.Conclusions: We define new aspects of a distinct neuropsychological profile in patients with acromegaly, which are largely independent of disease activity. Chronic physical complaints are more pronounced in patients than in controls, with exhaustion and general complaints showing no association with disease activity.https://www.frontiersin.org/article/10.3389/fendo.2018.00391/fullneuropsychological profilephysical complaintsacromegalydisease activitypituitary insufficiency |
| spellingShingle | Anca Zimmermann Rüdiger Zwerenz Michael Droste Christof Schöfl Christian J. Strasburger Ursula Plöckinger Athanasia Ziagaki Jürgen Honegger Anne Dixius Bledar Millaku Gerrit Toenges Manfred E. Beutel Matthias M. Weber Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors Frontiers in Endocrinology neuropsychological profile physical complaints acromegaly disease activity pituitary insufficiency |
| title | Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors |
| title_full | Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors |
| title_fullStr | Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors |
| title_full_unstemmed | Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors |
| title_short | Personality Traits and Physical Complaints in Patients With Acromegaly: A Cross Sectional Multi-Center Study With Analysis of Influencing Factors |
| title_sort | personality traits and physical complaints in patients with acromegaly a cross sectional multi center study with analysis of influencing factors |
| topic | neuropsychological profile physical complaints acromegaly disease activity pituitary insufficiency |
| url | https://www.frontiersin.org/article/10.3389/fendo.2018.00391/full |
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