Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers
Betanin is a bioactive compound with a high antioxidant activity and therapeutic potential. However, incomplete oral absorption and low stability of betanin limit its application. To surmount these limitations, betanin was encapsulated with nanoliposomes, nanoparticles exhibiting suitable physicoche...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-08-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619302713 |
| _version_ | 1828962567154827264 |
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| author | Sajed Amjadi Mehran Mesgari Abbasi Behrooz Shokouhi Marjan Ghorbani Hamed Hamishehkar |
| author_facet | Sajed Amjadi Mehran Mesgari Abbasi Behrooz Shokouhi Marjan Ghorbani Hamed Hamishehkar |
| author_sort | Sajed Amjadi |
| collection | DOAJ |
| description | Betanin is a bioactive compound with a high antioxidant activity and therapeutic potential. However, incomplete oral absorption and low stability of betanin limit its application. To surmount these limitations, betanin was encapsulated with nanoliposomes, nanoparticles exhibiting suitable physicochemical properties. Additionally, betanin-loaded nanoliposomes revealed a relatively good sustained release profile in the simulated gastric and intestinal fluids. In vitro digestion stability of betanin and its antioxidant activity were significantly improved by liposomal encapsulation. These nanocarriers were assessed in vivo for their therapeutic potency in streptozotocin induced rats. The results showed that the administration of betanin-loaded nanoliposomes was significantly more effective than free betanin in positively regulate hyperglycemia, hyperlipidemia and oxidative stress. Moreover, the histopathological analysis showed that the tissue damage in kidney, liver and pancreas was reduced in the betanin-loaded nanoliposomes treated diabetic rats. In conclusion nanoliposomes are suitable nanocarriers for improving the stability and therapeutic potential of betanin. |
| first_indexed | 2024-12-14T10:07:49Z |
| format | Article |
| id | doaj.art-e4ea7ee1b18f4458b22fae72bcd7252d |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-14T10:07:49Z |
| publishDate | 2019-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e4ea7ee1b18f4458b22fae72bcd7252d2022-12-21T23:07:06ZengElsevierJournal of Functional Foods1756-46462019-08-0159119128Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriersSajed Amjadi0Mehran Mesgari Abbasi1Behrooz Shokouhi2Marjan Ghorbani3Hamed Hamishehkar4Department of Food Science and Technology, Faculty of Agriculture, Urmia University, Urmia, Iran; Biotechnology Research Center, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, IranDepartment of Pathology, Tabriz University of Medical Sciences, Tabriz, IranStem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, IranDrug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Corresponding author at: Drug Applied Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.Betanin is a bioactive compound with a high antioxidant activity and therapeutic potential. However, incomplete oral absorption and low stability of betanin limit its application. To surmount these limitations, betanin was encapsulated with nanoliposomes, nanoparticles exhibiting suitable physicochemical properties. Additionally, betanin-loaded nanoliposomes revealed a relatively good sustained release profile in the simulated gastric and intestinal fluids. In vitro digestion stability of betanin and its antioxidant activity were significantly improved by liposomal encapsulation. These nanocarriers were assessed in vivo for their therapeutic potency in streptozotocin induced rats. The results showed that the administration of betanin-loaded nanoliposomes was significantly more effective than free betanin in positively regulate hyperglycemia, hyperlipidemia and oxidative stress. Moreover, the histopathological analysis showed that the tissue damage in kidney, liver and pancreas was reduced in the betanin-loaded nanoliposomes treated diabetic rats. In conclusion nanoliposomes are suitable nanocarriers for improving the stability and therapeutic potential of betanin.http://www.sciencedirect.com/science/article/pii/S1756464619302713BetaninNanoliposomesSustained releaseDigestion stabilityDiabetes |
| spellingShingle | Sajed Amjadi Mehran Mesgari Abbasi Behrooz Shokouhi Marjan Ghorbani Hamed Hamishehkar Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers Journal of Functional Foods Betanin Nanoliposomes Sustained release Digestion stability Diabetes |
| title | Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers |
| title_full | Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers |
| title_fullStr | Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers |
| title_full_unstemmed | Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers |
| title_short | Enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers |
| title_sort | enhancement of therapeutic efficacy of betanin for diabetes treatment by liposomal nanocarriers |
| topic | Betanin Nanoliposomes Sustained release Digestion stability Diabetes |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619302713 |
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