Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis
Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is k...
| Main Authors: | , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-06-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019304608 |
| _version_ | 1819138426513915904 |
|---|---|
| author | Luane Lopes Pinheiro Ana Rita de Lima Danielli Martinelli Martins Edivaldo Herculano C. de Oliveira Michel Platini C. Souza Carla Maria Figueiredo de Carvalho Miranda Patrícia Cristina Baleeiro Beltrão-Braga Fabiele Baldino Russo Graciela Conceição Pignatari Ednaldo da Silva Filho Érika Branco |
| author_facet | Luane Lopes Pinheiro Ana Rita de Lima Danielli Martinelli Martins Edivaldo Herculano C. de Oliveira Michel Platini C. Souza Carla Maria Figueiredo de Carvalho Miranda Patrícia Cristina Baleeiro Beltrão-Braga Fabiele Baldino Russo Graciela Conceição Pignatari Ednaldo da Silva Filho Érika Branco |
| author_sort | Luane Lopes Pinheiro |
| collection | DOAJ |
| description | Researchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis. |
| first_indexed | 2024-12-22T11:06:35Z |
| format | Article |
| id | doaj.art-e4eb02ca82d449089ffd5f73802735ef |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-22T11:06:35Z |
| publishDate | 2019-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e4eb02ca82d449089ffd5f73802735ef2022-12-21T18:28:17ZengElsevierHeliyon2405-84402019-06-0156e01857Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosisLuane Lopes Pinheiro0Ana Rita de Lima1Danielli Martinelli Martins2Edivaldo Herculano C. de Oliveira3Michel Platini C. Souza4Carla Maria Figueiredo de Carvalho Miranda5Patrícia Cristina Baleeiro Beltrão-Braga6Fabiele Baldino Russo7Graciela Conceição Pignatari8Ednaldo da Silva Filho9Érika Branco10Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, PA, Brazil; Corresponding author.Institute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, PA, BrazilInstitute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, PA, BrazilTissue Culture and Cytogenetics Laboratory of the Environment Sector, Instituto Evandro Chagas, Ananindeua, PA, BrazilTissue Culture and Cytogenetics Laboratory of the Environment Sector, Instituto Evandro Chagas, Ananindeua, PA, BrazilDepartment of Surgery, Faculty of Veterinary Medicine and Animal Science, University of São Paulo, São Paulo, SP, BrazilInstitute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, SP, BrazilInstitute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, SP, BrazilInstitute of Biomedical Sciences, Department of Microbiology, University of São Paulo, São Paulo, SP, BrazilInstitute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, PA, BrazilInstitute of Animal Health and Production, Faculty of Veterinary Medicine, Federal Rural University of Amazonia, Belém, PA, BrazilResearchers have used dogs with neurological sequelae caused by distemper as an experimental model for multiple sclerosis, owing to the similarities of the neuropathological changes between distemper virus-induced demyelinating leukoencephalitis and multiple sclerosis in humans. However, little is known about the role of mesenchymal stem cells in treating such clinical conditions. Therefore, we investigated the use of mesenchymal stem cells in four dogs with neurological lesions caused by the distemper virus. During the first year after cellular therapy, the animals did not demonstrate significant changes in their locomotive abilities. However, the intense (Grade V) myoclonus in three animals was reduced to a moderate (Grade IV) level. At one year after the mesenchymal stem cell infusions, three animals regained functional ambulation (Grade I), and all four dogs started to move independently (Grades I and II). In two animals, the myoclonic severity had become mild (Grade III). It was concluded that the use of mesenchymal stem cells could improve the quality of life of dogs with neurological sequelae caused by canine distemper, thus presenting hope for similar positive results in human patients with multiple sclerosis.http://www.sciencedirect.com/science/article/pii/S2405844019304608Cell biologyNeuroscienceMesenchymal stem cellsCanine distemperMultiple sclerosisDemyelination |
| spellingShingle | Luane Lopes Pinheiro Ana Rita de Lima Danielli Martinelli Martins Edivaldo Herculano C. de Oliveira Michel Platini C. Souza Carla Maria Figueiredo de Carvalho Miranda Patrícia Cristina Baleeiro Beltrão-Braga Fabiele Baldino Russo Graciela Conceição Pignatari Ednaldo da Silva Filho Érika Branco Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis Heliyon Cell biology Neuroscience Mesenchymal stem cells Canine distemper Multiple sclerosis Demyelination |
| title | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_full | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_fullStr | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_full_unstemmed | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_short | Mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| title_sort | mesenchymal stem cells in dogs with demyelinating leukoencephalitis as an experimental model of multiple sclerosis |
| topic | Cell biology Neuroscience Mesenchymal stem cells Canine distemper Multiple sclerosis Demyelination |
| url | http://www.sciencedirect.com/science/article/pii/S2405844019304608 |
| work_keys_str_mv | AT luanelopespinheiro mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT anaritadelima mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT daniellimartinellimartins mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT edivaldoherculanocdeoliveira mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT michelplatinicsouza mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT carlamariafigueiredodecarvalhomiranda mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT patriciacristinabaleeirobeltraobraga mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT fabielebaldinorusso mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT gracielaconceicaopignatari mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT ednaldodasilvafilho mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis AT erikabranco mesenchymalstemcellsindogswithdemyelinatingleukoencephalitisasanexperimentalmodelofmultiplesclerosis |