Advances in genetic variation in metabolism-related fatty liver disease
Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver disease in the world. Its pathogenesis is influenced by both environmental and genetic factors. With the upgrading of gene screening methods and the development of human genome project, whole genome scanning has...
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| Format: | Article |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2023.1213916/full |
| _version_ | 1797688928764952576 |
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| author | Fan Shi Mei Zhao Shudan Zheng Lihong Zheng Haiqiang Wang |
| author_facet | Fan Shi Mei Zhao Shudan Zheng Lihong Zheng Haiqiang Wang |
| author_sort | Fan Shi |
| collection | DOAJ |
| description | Metabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver disease in the world. Its pathogenesis is influenced by both environmental and genetic factors. With the upgrading of gene screening methods and the development of human genome project, whole genome scanning has been widely used to screen genes related to MAFLD, and more and more genetic variation factors related to MAFLD susceptibility have been discovered. There are genetic variants that are highly correlated with the occurrence and development of MAFLD, and there are genetic variants that are protective of MAFLD. These genetic variants affect the development of MAFLD by influencing lipid metabolism and insulin resistance. Therefore, in-depth analysis of different mechanisms of genetic variation and targeting of specific genetic variation genes may provide a new idea for the early prediction and diagnosis of diseases and individualized precision therapy, which may be a promising strategy for the treatment of MAFLD. |
| first_indexed | 2024-03-12T01:38:38Z |
| format | Article |
| id | doaj.art-e4ed60ad7bab4a5298048971be3c37a7 |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-03-12T01:38:38Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-e4ed60ad7bab4a5298048971be3c37a72023-09-11T04:38:19ZengFrontiers Media S.A.Frontiers in Genetics1664-80212023-09-011410.3389/fgene.2023.12139161213916Advances in genetic variation in metabolism-related fatty liver diseaseFan Shi0Mei Zhao1Shudan Zheng2Lihong Zheng3Haiqiang Wang4School of Heilongjiang University of Chinese Medicine, Harbin, ChinaSchool of Heilongjiang University of Chinese Medicine, Harbin, ChinaSchool of Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Internal Medicine, Fourth Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaDepartment of Internal Medicine, First Affiliated Hospital, Heilongjiang University of Chinese Medicine, Harbin, ChinaMetabolism-related fatty liver disease (MAFLD) is the most common form of chronic liver disease in the world. Its pathogenesis is influenced by both environmental and genetic factors. With the upgrading of gene screening methods and the development of human genome project, whole genome scanning has been widely used to screen genes related to MAFLD, and more and more genetic variation factors related to MAFLD susceptibility have been discovered. There are genetic variants that are highly correlated with the occurrence and development of MAFLD, and there are genetic variants that are protective of MAFLD. These genetic variants affect the development of MAFLD by influencing lipid metabolism and insulin resistance. Therefore, in-depth analysis of different mechanisms of genetic variation and targeting of specific genetic variation genes may provide a new idea for the early prediction and diagnosis of diseases and individualized precision therapy, which may be a promising strategy for the treatment of MAFLD.https://www.frontiersin.org/articles/10.3389/fgene.2023.1213916/fullMAFLDgenetic variationPNPLA3HSD17B13therapeutic potential |
| spellingShingle | Fan Shi Mei Zhao Shudan Zheng Lihong Zheng Haiqiang Wang Advances in genetic variation in metabolism-related fatty liver disease Frontiers in Genetics MAFLD genetic variation PNPLA3 HSD17B13 therapeutic potential |
| title | Advances in genetic variation in metabolism-related fatty liver disease |
| title_full | Advances in genetic variation in metabolism-related fatty liver disease |
| title_fullStr | Advances in genetic variation in metabolism-related fatty liver disease |
| title_full_unstemmed | Advances in genetic variation in metabolism-related fatty liver disease |
| title_short | Advances in genetic variation in metabolism-related fatty liver disease |
| title_sort | advances in genetic variation in metabolism related fatty liver disease |
| topic | MAFLD genetic variation PNPLA3 HSD17B13 therapeutic potential |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2023.1213916/full |
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