Exploring the role of CHI3L1 in pre-metastatic lungs of mammary tumor-bearing mice

Exploring the role of CHI3L1 in pre-metastatic lungs of mammary tumor-bearing mice

Elevated levels of chitinase-3-like-1 (CHI3L1) are associated with poor prognosis, shorter recurrence-free intervals and low survival in breast cancer patients. Breast cancer often metastasizes to the lung. We hypothesized that molecules expressed in the pre-metastatic lung microenvironment could...

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Bibliographic Details
Main Authors: Stephania eLibreros, Ramon eGarcia-Areas, Patricia eKeating, Roberto eCarrio, Vijaya eIragavarapu-Charyulu
Format: Article
Language:English
Published: Frontiers Media S.A. 2013-12-01
Series:Frontiers in Physiology
Subjects:
Macrophages
Tumor growth
Angiogenesis
CHI3L1
chitin microparticles
pulmonary environment
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2013.00392/full

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