Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor
Background and objectives: Very low birth weight (VLBW) infants are at high risk of developing acute kidney injury (AKI), presumably secondary to low kidney reserves, stressful postnatal events, and drug exposures. Our study aimed to identify the prevalence, risk factors, and outcomes associated wit...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Children |
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| Online Access: | https://www.mdpi.com/2227-9067/10/2/242 |
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| author | Gilad Lazarovits Noa Ofek Shlomai Raed Kheir Tali Bdolah Abram Smadar Eventov Friedman Oded Volovelsky |
| author_facet | Gilad Lazarovits Noa Ofek Shlomai Raed Kheir Tali Bdolah Abram Smadar Eventov Friedman Oded Volovelsky |
| author_sort | Gilad Lazarovits |
| collection | DOAJ |
| description | Background and objectives: Very low birth weight (VLBW) infants are at high risk of developing acute kidney injury (AKI), presumably secondary to low kidney reserves, stressful postnatal events, and drug exposures. Our study aimed to identify the prevalence, risk factors, and outcomes associated with AKI in VLBW infants. Study design: Records of all VLBW infants admitted to two medical campuses between January 2019 and June 2020 were retrospectively reviewed. AKI was classified using the modified KDIGO definition to include only serum creatinine. Risk factors and composite outcomes were compared between infants with and without AKI. We evaluated the main predictors of AKI and death with forward stepwise regression analysis. Results: 152 VLBW infants were enrolled. 21% of them developed AKI. Based on the multivariable analysis, the most significant predictors of AKI were the use of vasopressors, patent ductus arteriosus, and bloodstream infection. AKI had a strong and independent association with neonatal mortality. Conclusions: AKI is common in VLBW infants and is a significant risk factor for mortality. Efforts to prevent AKI are necessary to prevent its harmful effects. |
| first_indexed | 2024-03-11T09:00:25Z |
| format | Article |
| id | doaj.art-e4ee46316e744df38e5ecfea3904f9fa |
| institution | Directory Open Access Journal |
| issn | 2227-9067 |
| language | English |
| last_indexed | 2024-03-11T09:00:25Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Children |
| spelling | doaj.art-e4ee46316e744df38e5ecfea3904f9fa2023-11-16T19:48:00ZengMDPI AGChildren2227-90672023-01-0110224210.3390/children10020242Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk FactorGilad Lazarovits0Noa Ofek Shlomai1Raed Kheir2Tali Bdolah Abram3Smadar Eventov Friedman4Oded Volovelsky5Department of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, IsraelDepartment of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, IsraelSchool of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, IsraelSchool of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, IsraelDepartment of Neonatology, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, IsraelSchool of Medicine, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190501, IsraelBackground and objectives: Very low birth weight (VLBW) infants are at high risk of developing acute kidney injury (AKI), presumably secondary to low kidney reserves, stressful postnatal events, and drug exposures. Our study aimed to identify the prevalence, risk factors, and outcomes associated with AKI in VLBW infants. Study design: Records of all VLBW infants admitted to two medical campuses between January 2019 and June 2020 were retrospectively reviewed. AKI was classified using the modified KDIGO definition to include only serum creatinine. Risk factors and composite outcomes were compared between infants with and without AKI. We evaluated the main predictors of AKI and death with forward stepwise regression analysis. Results: 152 VLBW infants were enrolled. 21% of them developed AKI. Based on the multivariable analysis, the most significant predictors of AKI were the use of vasopressors, patent ductus arteriosus, and bloodstream infection. AKI had a strong and independent association with neonatal mortality. Conclusions: AKI is common in VLBW infants and is a significant risk factor for mortality. Efforts to prevent AKI are necessary to prevent its harmful effects.https://www.mdpi.com/2227-9067/10/2/242acute kidney injuryvery low birth weightpatent ductus arteriosusbloodstream infectionsvasopressorsprematurity |
| spellingShingle | Gilad Lazarovits Noa Ofek Shlomai Raed Kheir Tali Bdolah Abram Smadar Eventov Friedman Oded Volovelsky Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor Children acute kidney injury very low birth weight patent ductus arteriosus bloodstream infections vasopressors prematurity |
| title | Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor |
| title_full | Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor |
| title_fullStr | Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor |
| title_full_unstemmed | Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor |
| title_short | Acute Kidney Injury in Very Low Birth Weight Infants: A Major Morbidity and Mortality Risk Factor |
| title_sort | acute kidney injury in very low birth weight infants a major morbidity and mortality risk factor |
| topic | acute kidney injury very low birth weight patent ductus arteriosus bloodstream infections vasopressors prematurity |
| url | https://www.mdpi.com/2227-9067/10/2/242 |
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