Elicitation of Highly Pathogenic Avian Influenza H5N1 M2e and HA2-Specific Humoral and Cell-Mediated Immune Response in Chicken Following Immunization With Recombinant M2e–HA2 Fusion Protein

Elicitation of Highly Pathogenic Avian Influenza H5N1 M2e and HA2-Specific Humoral and Cell-Mediated Immune Response in Chicken Following Immunization With Recombinant M2e–HA2 Fusion Protein

The study was aimed to evaluate the elicitation of highly pathogenic avian influenza (HPAI) virus (AIV) M2e and HA2-specific immunity in chicken to develop broad protective influenza vaccine against HPAI H5N1. Based on the analysis of Indian AIV H5N1 sequences, the conserved regions of extracellular...

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Bibliographic Details
Main Authors: Semmannan Kalaiyarasu, Sandeep Bhatia, Niranjan Mishra, Dhanapal Senthil Kumar, Manoj Kumar, Richa Sood, Katherukamem Rajukumar, Boopathi Ponnusamy, Dhruv Desai, Vijendra Pal Singh
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-02-01
Series:Frontiers in Veterinary Science
Subjects:
avian influenza
immunity
matrix and hemagglutinin
humoral and cell mediated immunity
recombinant protein
Online Access:https://www.frontiersin.org/articles/10.3389/fvets.2020.571999/full

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