Microbiome dysbiosis in lung cancer: from composition to therapy
Abstract The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a...
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2020-12-01
|
| Series: | npj Precision Oncology |
| Online Access: | https://doi.org/10.1038/s41698-020-00138-z |
| _version_ | 1827616265555935232 |
|---|---|
| author | Ning-Ning Liu Qiang Ma Yang Ge Cheng-Xiang Yi Lu-Qi Wei Jing-Cong Tan Qiao Chu Jing-Quan Li Peng Zhang Hui Wang |
| author_facet | Ning-Ning Liu Qiang Ma Yang Ge Cheng-Xiang Yi Lu-Qi Wei Jing-Cong Tan Qiao Chu Jing-Quan Li Peng Zhang Hui Wang |
| author_sort | Ning-Ning Liu |
| collection | DOAJ |
| description | Abstract The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract. Although previous findings uncovered the critical roles of microbiota in tumorigenesis and response to anticancer therapy, most of them were focused on the intestinal microbiota rather than lung microbiota. Notably, the considerable functions of microbiota in maintaining lung homeostasis should not be neglected as the microbiome dysbiosis may promote tumor development and progression through production of cytokines and toxins and multiple other pathways. Despite the fact that increasing studies have revealed the effect of microbiome on the induction of lung cancer and different disease status, the underlying mechanisms and potential therapeutic strategies remained unclear. Herein, we summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression and the current status of therapeutic approaches targeting microbiome to alleviate and even cure lung cancer. |
| first_indexed | 2024-03-09T09:24:31Z |
| format | Article |
| id | doaj.art-e4f4d1a8db154fe3bbc82672755c4f4c |
| institution | Directory Open Access Journal |
| issn | 2397-768X |
| language | English |
| last_indexed | 2024-03-09T09:24:31Z |
| publishDate | 2020-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Precision Oncology |
| spelling | doaj.art-e4f4d1a8db154fe3bbc82672755c4f4c2023-12-02T06:47:59ZengNature Portfolionpj Precision Oncology2397-768X2020-12-014111210.1038/s41698-020-00138-zMicrobiome dysbiosis in lung cancer: from composition to therapyNing-Ning Liu0Qiang Ma1Yang Ge2Cheng-Xiang Yi3Lu-Qi Wei4Jing-Cong Tan5Qiao Chu6Jing-Quan Li7Peng Zhang8Hui Wang9State Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji UniversityState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji UniversityState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineDepartment of Thoracic Surgery, Shanghai Pulmonary Hospital Tongji UniversityState Key Laboratory of Oncogenes and Related Genes, Center for Single-Cell Omics, School of Public Health, Shanghai Jiao Tong University School of MedicineAbstract The correlations between microbiota dysbiosis and cancer have gained extensive attention and been widely explored. As a leading cancer diagnosis worldwide, lung cancer poses a great threat to human health. The healthy human lungs are consistently exposed to external environment and harbor a specific pattern of microbiota, sharing many key pathological and physiological characteristics with the intestinal tract. Although previous findings uncovered the critical roles of microbiota in tumorigenesis and response to anticancer therapy, most of them were focused on the intestinal microbiota rather than lung microbiota. Notably, the considerable functions of microbiota in maintaining lung homeostasis should not be neglected as the microbiome dysbiosis may promote tumor development and progression through production of cytokines and toxins and multiple other pathways. Despite the fact that increasing studies have revealed the effect of microbiome on the induction of lung cancer and different disease status, the underlying mechanisms and potential therapeutic strategies remained unclear. Herein, we summarized the recent progresses about microbiome in lung cancer and further discussed the role of microbial communities in promoting lung cancer progression and the current status of therapeutic approaches targeting microbiome to alleviate and even cure lung cancer.https://doi.org/10.1038/s41698-020-00138-z |
| spellingShingle | Ning-Ning Liu Qiang Ma Yang Ge Cheng-Xiang Yi Lu-Qi Wei Jing-Cong Tan Qiao Chu Jing-Quan Li Peng Zhang Hui Wang Microbiome dysbiosis in lung cancer: from composition to therapy npj Precision Oncology |
| title | Microbiome dysbiosis in lung cancer: from composition to therapy |
| title_full | Microbiome dysbiosis in lung cancer: from composition to therapy |
| title_fullStr | Microbiome dysbiosis in lung cancer: from composition to therapy |
| title_full_unstemmed | Microbiome dysbiosis in lung cancer: from composition to therapy |
| title_short | Microbiome dysbiosis in lung cancer: from composition to therapy |
| title_sort | microbiome dysbiosis in lung cancer from composition to therapy |
| url | https://doi.org/10.1038/s41698-020-00138-z |
| work_keys_str_mv | AT ningningliu microbiomedysbiosisinlungcancerfromcompositiontotherapy AT qiangma microbiomedysbiosisinlungcancerfromcompositiontotherapy AT yangge microbiomedysbiosisinlungcancerfromcompositiontotherapy AT chengxiangyi microbiomedysbiosisinlungcancerfromcompositiontotherapy AT luqiwei microbiomedysbiosisinlungcancerfromcompositiontotherapy AT jingcongtan microbiomedysbiosisinlungcancerfromcompositiontotherapy AT qiaochu microbiomedysbiosisinlungcancerfromcompositiontotherapy AT jingquanli microbiomedysbiosisinlungcancerfromcompositiontotherapy AT pengzhang microbiomedysbiosisinlungcancerfromcompositiontotherapy AT huiwang microbiomedysbiosisinlungcancerfromcompositiontotherapy |