Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study
Abstract Background Osteoporosis is a major health concern for both men and women, and associated fractures incur substantial economic burden. While there are a multitude of studies on bone mineral density (BMD) and liver diseases, not many studies have assessed the association between liver enzyme...
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| Format: | Article |
| Language: | English |
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BMC
2018-11-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12891-018-2322-1 |
| _version_ | 1828531884461654016 |
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| author | Ho Jeong Do Joon-Shik Shin Jinho Lee Yoon Jae Lee Me-riong Kim Dongwoo Nam Eun-Jung Kim Yeoncheol Park Kristin Suhr In-Hyuk Ha |
| author_facet | Ho Jeong Do Joon-Shik Shin Jinho Lee Yoon Jae Lee Me-riong Kim Dongwoo Nam Eun-Jung Kim Yeoncheol Park Kristin Suhr In-Hyuk Ha |
| author_sort | Ho Jeong Do |
| collection | DOAJ |
| description | Abstract Background Osteoporosis is a major health concern for both men and women, and associated fractures incur substantial economic burden. While there are a multitude of studies on bone mineral density (BMD) and liver diseases, not many studies have assessed the association between liver enzyme levels and BMD in homogeneous populations. Methods The current study investigated the association between serum liver enzyme levels and BMD at various sites in Koreans. Out of 21,517 surveyees of the 5th Korean National Health and Nutrition Examination Survey (2010–2012), 7160 participants’ data on BMD, serum liver enzymes, and full covariate data were included for cross-sectional analysis. BMD at the femoral neck, lumbar spine, entire femur, and whole body was assessed using dual energy X-ray absorptiometry (DEXA), and liver enzymes included aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma(γ)-glutamyl transferase (GGT) levels. Differences in participant characteristics by BMD and liver enzyme levels were analyzed, and complex sample design regression analysis adjusted for multiple covariates was performed to assess the relationship between liver enzymes and BMD. Results Negative associations were seen with GGT and BMD at all sites (P ≤ 0.02), ALT with lumbar spine (P = 0.0013), and AST with lumbar BMD (P = 0.0009). In particular, GGT presented strong negative associations with BMD in postmenopausal women and elder men. Conclusions This study demonstrates a negative relationship between liver enzyme levels and BMD, and suggests that a significant association exists between osteoporosis/decreased BMD and liver disorders. |
| first_indexed | 2024-12-11T22:45:03Z |
| format | Article |
| id | doaj.art-e4f863effddc4cc6a0b917095ca1f8ce |
| institution | Directory Open Access Journal |
| issn | 1471-2474 |
| language | English |
| last_indexed | 2024-12-11T22:45:03Z |
| publishDate | 2018-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj.art-e4f863effddc4cc6a0b917095ca1f8ce2022-12-22T00:47:39ZengBMCBMC Musculoskeletal Disorders1471-24742018-11-0119111310.1186/s12891-018-2322-1Association between liver enzymes and bone mineral density in Koreans: a cross-sectional studyHo Jeong Do0Joon-Shik Shin1Jinho Lee2Yoon Jae Lee3Me-riong Kim4Dongwoo Nam5Eun-Jung Kim6Yeoncheol Park7Kristin Suhr8In-Hyuk Ha9Jaseng Hospital of Korean Medicine, 536 Gangnam-daeroJaseng Hospital of Korean Medicine, 536 Gangnam-daeroJaseng Hospital of Korean Medicine, 536 Gangnam-daeroJaseng Spine and Joint Research Institute, Jaseng Medical FoundationJaseng Hospital of Korean Medicine, 536 Gangnam-daeroDepartment of Acupuncture & Moxibustion, College of Korean Medicine, Kyung Hee UniversityDepartment of Acupuncture & Moxibustion, College of Korean Medicine, Dongguk UniversityDepartment of Acupuncture & Moxibustion, Kyung Hee University Hospital at GangdongPrevention Sciences, Rollins School of Public Health, Emory UniversityJaseng Spine and Joint Research Institute, Jaseng Medical FoundationAbstract Background Osteoporosis is a major health concern for both men and women, and associated fractures incur substantial economic burden. While there are a multitude of studies on bone mineral density (BMD) and liver diseases, not many studies have assessed the association between liver enzyme levels and BMD in homogeneous populations. Methods The current study investigated the association between serum liver enzyme levels and BMD at various sites in Koreans. Out of 21,517 surveyees of the 5th Korean National Health and Nutrition Examination Survey (2010–2012), 7160 participants’ data on BMD, serum liver enzymes, and full covariate data were included for cross-sectional analysis. BMD at the femoral neck, lumbar spine, entire femur, and whole body was assessed using dual energy X-ray absorptiometry (DEXA), and liver enzymes included aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma(γ)-glutamyl transferase (GGT) levels. Differences in participant characteristics by BMD and liver enzyme levels were analyzed, and complex sample design regression analysis adjusted for multiple covariates was performed to assess the relationship between liver enzymes and BMD. Results Negative associations were seen with GGT and BMD at all sites (P ≤ 0.02), ALT with lumbar spine (P = 0.0013), and AST with lumbar BMD (P = 0.0009). In particular, GGT presented strong negative associations with BMD in postmenopausal women and elder men. Conclusions This study demonstrates a negative relationship between liver enzyme levels and BMD, and suggests that a significant association exists between osteoporosis/decreased BMD and liver disorders.http://link.springer.com/article/10.1186/s12891-018-2322-1OsteoporosisBone densityLiver function testsCross-sectional studiesHealth surveys |
| spellingShingle | Ho Jeong Do Joon-Shik Shin Jinho Lee Yoon Jae Lee Me-riong Kim Dongwoo Nam Eun-Jung Kim Yeoncheol Park Kristin Suhr In-Hyuk Ha Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study BMC Musculoskeletal Disorders Osteoporosis Bone density Liver function tests Cross-sectional studies Health surveys |
| title | Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study |
| title_full | Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study |
| title_fullStr | Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study |
| title_full_unstemmed | Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study |
| title_short | Association between liver enzymes and bone mineral density in Koreans: a cross-sectional study |
| title_sort | association between liver enzymes and bone mineral density in koreans a cross sectional study |
| topic | Osteoporosis Bone density Liver function tests Cross-sectional studies Health surveys |
| url | http://link.springer.com/article/10.1186/s12891-018-2322-1 |
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