Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

Lack of xanthine dehydrogenase leads to a remarkable renal decline in a novel hypouricemic rat model

Summary: Uric acid (UA) is the final metabolite in purine catabolism in humans. Previous studies have shown that the dysregulation of UA homeostasis is detrimental to cardiovascular and kidney health. The Xdh gene encodes for the Xanthine Oxidoreductase enzyme group, responsible for producing UA. To...

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Bibliographic Details
Main Authors: Lashodya V. Dissanayake, Adrian Zietara, Vladislav Levchenko, Denisha R. Spires, Mariana Burgos Angulo, Ashraf El-Meanawy, Aron M. Geurts, Melinda R. Dwinell, Oleg Palygin, Alexander Staruschenko
Format: Article
Language:English
Published: Elsevier 2022-09-01
Series:iScience
Subjects:
Biological sciences
Molecular physiology
Molecular biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222011592

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