The role of myeloid derived suppressor cells in musculoskeletal disorders
The immune system is closely linked to bone homeostasis and plays a pivotal role in several pathological and inflammatory conditions. Through various pathways it modulates various bone cells and subsequently sustains the physiological bone metabolism. Myeloid-derived suppressor cells (MDSCs) are a g...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-03-01
|
| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139683/full |
| _version_ | 1811160841469296640 |
|---|---|
| author | Yi Ren Henrik Bäcker Michael Müller Arne Kienzle Arne Kienzle |
| author_facet | Yi Ren Henrik Bäcker Michael Müller Arne Kienzle Arne Kienzle |
| author_sort | Yi Ren |
| collection | DOAJ |
| description | The immune system is closely linked to bone homeostasis and plays a pivotal role in several pathological and inflammatory conditions. Through various pathways it modulates various bone cells and subsequently sustains the physiological bone metabolism. Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous immature myeloid-derived cells that can exert an immunosuppressive function through a direct cell-to-cell contact, secretion of anti-inflammatory cytokines or specific exosomes. These cells mediate the innate immune response to chronic stress on the skeletal system. In chronic inflammation, MDSCs act as an inner offset to rebalance overactivation of the immune system. Moreover, they have been found to be involved in processes responsible for bone remodeling in different musculoskeletal disorders, autoimmune diseases, infection, and cancer. These cells can not only cause bone erosion by differentiating into osteoclasts, but also alleviate the immune reaction, subsequently leading to long-lastingly impacted bone remodeling. In this review, we discuss the impact of MDSCs on the bone metabolism under several pathological conditions, the involved modulatory pathways as well as potential therapeutic targets in MDSCs to improve bone health. |
| first_indexed | 2024-04-10T06:04:25Z |
| format | Article |
| id | doaj.art-e4fc0c188256494b8df4e4926da06981 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T06:04:25Z |
| publishDate | 2023-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-e4fc0c188256494b8df4e4926da069812023-03-03T05:06:46ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-03-011410.3389/fimmu.2023.11396831139683The role of myeloid derived suppressor cells in musculoskeletal disordersYi Ren0Henrik Bäcker1Michael Müller2Arne Kienzle3Arne Kienzle4Center for Musculoskeletal Surgery, Clinic for Orthopedics, Charité University Hospital, Berlin, GermanyDepartment of Orthopedics, Auckland City Hospital, Auckland, New ZealandCenter for Musculoskeletal Surgery, Clinic for Orthopedics, Charité University Hospital, Berlin, GermanyCenter for Musculoskeletal Surgery, Clinic for Orthopedics, Charité University Hospital, Berlin, GermanyBIH Charité Clinician Scientist Program, BIH Biomedical Innovation Academy, Berlin Institute of Health, Charité — Universitätsmedizin Berlin, Berlin, GermanyThe immune system is closely linked to bone homeostasis and plays a pivotal role in several pathological and inflammatory conditions. Through various pathways it modulates various bone cells and subsequently sustains the physiological bone metabolism. Myeloid-derived suppressor cells (MDSCs) are a group of heterogeneous immature myeloid-derived cells that can exert an immunosuppressive function through a direct cell-to-cell contact, secretion of anti-inflammatory cytokines or specific exosomes. These cells mediate the innate immune response to chronic stress on the skeletal system. In chronic inflammation, MDSCs act as an inner offset to rebalance overactivation of the immune system. Moreover, they have been found to be involved in processes responsible for bone remodeling in different musculoskeletal disorders, autoimmune diseases, infection, and cancer. These cells can not only cause bone erosion by differentiating into osteoclasts, but also alleviate the immune reaction, subsequently leading to long-lastingly impacted bone remodeling. In this review, we discuss the impact of MDSCs on the bone metabolism under several pathological conditions, the involved modulatory pathways as well as potential therapeutic targets in MDSCs to improve bone health.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139683/fullmyeloid derived suppressor cell (MDSC)bone metabolismosteoclastosteoblastimmune cellsinflammation |
| spellingShingle | Yi Ren Henrik Bäcker Michael Müller Arne Kienzle Arne Kienzle The role of myeloid derived suppressor cells in musculoskeletal disorders Frontiers in Immunology myeloid derived suppressor cell (MDSC) bone metabolism osteoclast osteoblast immune cells inflammation |
| title | The role of myeloid derived suppressor cells in musculoskeletal disorders |
| title_full | The role of myeloid derived suppressor cells in musculoskeletal disorders |
| title_fullStr | The role of myeloid derived suppressor cells in musculoskeletal disorders |
| title_full_unstemmed | The role of myeloid derived suppressor cells in musculoskeletal disorders |
| title_short | The role of myeloid derived suppressor cells in musculoskeletal disorders |
| title_sort | role of myeloid derived suppressor cells in musculoskeletal disorders |
| topic | myeloid derived suppressor cell (MDSC) bone metabolism osteoclast osteoblast immune cells inflammation |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1139683/full |
| work_keys_str_mv | AT yiren theroleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT henrikbacker theroleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT michaelmuller theroleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT arnekienzle theroleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT arnekienzle theroleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT yiren roleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT henrikbacker roleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT michaelmuller roleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT arnekienzle roleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders AT arnekienzle roleofmyeloidderivedsuppressorcellsinmusculoskeletaldisorders |