ATP12A Proton Pump as an Emerging Therapeutic Target in Cystic Fibrosis and Other Respiratory Diseases

ATP12A Proton Pump as an Emerging Therapeutic Target in Cystic Fibrosis and Other Respiratory Diseases

<i>ATP12A</i> encodes the catalytic subunit of the non-gastric proton pump, which is expressed in many epithelial tissues and mediates the secretion of protons in exchange for potassium ions. In the airways, ATP12A-dependent proton secretion contributes to complex mechanisms regulating t...

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Bibliographic Details
Main Authors: Michał Dębczyński, Giulia Gorrieri, Damian Mojsak, Floriana Guida, Federico Zara, Paolo Scudieri
Format: Article
Language:English
Published: MDPI AG 2023-09-01
Series:Biomolecules
Subjects:
ATP12A
modifier genes
airway acidification
cystic fibrosis
ASL
proton transport
Online Access:https://www.mdpi.com/2218-273X/13/10/1455

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