The Vacuolating Autotransporter Toxin (Vat) of Escherichia coli Causes Cell Cytoskeleton Changes and Produces Non-lysosomal Vacuole Formation in Bladder Epithelial Cells

The Vacuolating Autotransporter Toxin (Vat) of Escherichia coli Causes Cell Cytoskeleton Changes and Produces Non-lysosomal Vacuole Formation in Bladder Epithelial Cells

Urinary tract infections (UTIs) affect more than 150 million people, with a cost of over 3.5 billion dollars, each year. Escherichia coli is associated with 70–80% of UTIs. Uropathogenic E. coli (UPEC) has virulence factors including adhesins, siderophores, and toxins that damage host cells. Vacuola...

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Bibliographic Details
Main Authors: Juan Manuel Díaz, Charles M. Dozois, Francisco Javier Avelar-González, Eduardo Hernández-Cuellar, Pravil Pokharel, Alfredo Salazar de Santiago, Alma Lilian Guerrero-Barrera
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-06-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
urinary tract infection
Escherichia coli
virulence factors
vat
cell damage
vacuoles
Online Access:https://www.frontiersin.org/article/10.3389/fcimb.2020.00299/full

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