Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications
Given their relevance in various physiological and pathophysiological mechanisms, gaseous signaling molecules (GSMs), such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), are promising therapeutics for derailing various diseases at precisely controlled concentrations. However...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-06-01
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| Series: | Giant |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666542523000152 |
| _version_ | 1827923319852105728 |
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| author | Ishaq Lugoloobi Yuanmeng Fang Faxing Jiang Guoying Zhang Jinming Hu |
| author_facet | Ishaq Lugoloobi Yuanmeng Fang Faxing Jiang Guoying Zhang Jinming Hu |
| author_sort | Ishaq Lugoloobi |
| collection | DOAJ |
| description | Given their relevance in various physiological and pathophysiological mechanisms, gaseous signaling molecules (GSMs), such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), are promising therapeutics for derailing various diseases at precisely controlled concentrations. However, the delivery and release of GSMs have been challenged by the heterogeneity of biological systems. Carefully constructed hybrid materials have exhibited enhanced functional ability owing to the adjusted individual characteristics. In this minireview, we surveyed the mechanisms of gas therapy, recent exceptional studies on the controlled release of GSMs from hybrid nanoplatforms, and their applications in the treatment of various diseases. Single gas therapies and their combined modalities with conventional treatments such as chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), and immunotherapy have been summarized, with critical analysis of the contribution of the metallic elements in the various nanoplatforms. Moreover, the challenges and prospects of hybrid GSM releasers as promising healings have been discussed. |
| first_indexed | 2024-03-13T04:55:03Z |
| format | Article |
| id | doaj.art-e4ffdde901c2483880ec6eb7e07947d7 |
| institution | Directory Open Access Journal |
| issn | 2666-5425 |
| language | English |
| last_indexed | 2024-03-13T04:55:03Z |
| publishDate | 2023-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Giant |
| spelling | doaj.art-e4ffdde901c2483880ec6eb7e07947d72023-06-18T05:03:27ZengElsevierGiant2666-54252023-06-0114100153Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applicationsIshaq Lugoloobi0Yuanmeng Fang1Faxing Jiang2Guoying Zhang3Jinming Hu4Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, ChinaDepartment of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, ChinaDepartment of Dermatology, the First Affiliated Hospital University of Science and Technology of China, University of Science and Technology of China, Hefei 230001, China; Correspondings author at: Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China; Correspondings author at: Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China; Correspondings author at: Department of Pharmacy, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, School of Chemistry and Materials Science, University of Science and Technology of China, Hefei, Anhui 230026, China.Given their relevance in various physiological and pathophysiological mechanisms, gaseous signaling molecules (GSMs), such as nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), are promising therapeutics for derailing various diseases at precisely controlled concentrations. However, the delivery and release of GSMs have been challenged by the heterogeneity of biological systems. Carefully constructed hybrid materials have exhibited enhanced functional ability owing to the adjusted individual characteristics. In this minireview, we surveyed the mechanisms of gas therapy, recent exceptional studies on the controlled release of GSMs from hybrid nanoplatforms, and their applications in the treatment of various diseases. Single gas therapies and their combined modalities with conventional treatments such as chemotherapy, photodynamic therapy (PDT), photothermal therapy (PTT), and immunotherapy have been summarized, with critical analysis of the contribution of the metallic elements in the various nanoplatforms. Moreover, the challenges and prospects of hybrid GSM releasers as promising healings have been discussed.http://www.sciencedirect.com/science/article/pii/S2666542523000152Hybrid nanomaterialsGaseous signaling moleculesNitric oxideCarbon monoxideHydrogen sulfide |
| spellingShingle | Ishaq Lugoloobi Yuanmeng Fang Faxing Jiang Guoying Zhang Jinming Hu Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications Giant Hybrid nanomaterials Gaseous signaling molecules Nitric oxide Carbon monoxide Hydrogen sulfide |
| title | Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications |
| title_full | Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications |
| title_fullStr | Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications |
| title_full_unstemmed | Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications |
| title_short | Gaseous signaling molecule-releasing hybrid nanomaterials for therapeutic applications |
| title_sort | gaseous signaling molecule releasing hybrid nanomaterials for therapeutic applications |
| topic | Hybrid nanomaterials Gaseous signaling molecules Nitric oxide Carbon monoxide Hydrogen sulfide |
| url | http://www.sciencedirect.com/science/article/pii/S2666542523000152 |
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