Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

Hypertrophic chondrocytes serve as a reservoir for marrow-associated skeletal stem and progenitor cells, osteoblasts, and adipocytes during skeletal development

Hypertrophic chondrocytes give rise to osteoblasts during skeletal development; however, the process by which these non-mitotic cells make this transition is not well understood. Prior studies have also suggested that skeletal stem and progenitor cells (SSPCs) localize to the surrounding periosteum...

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Bibliographic Details
Main Authors: Jason T Long, Abigail Leinroth, Yihan Liao, Yinshi Ren, Anthony J Mirando, Tuyet Nguyen, Wendi Guo, Deepika Sharma, Douglas Rouse, Colleen Wu, Kathryn Song Eng Cheah, Courtney M Karner, Matthew J Hilton
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-02-01
Series:eLife
Subjects:
hypertrophic chondrocytes
osteoblasts
adipocytes
bone marrow
progenitor cells
skeletal stem
Online Access:https://elifesciences.org/articles/76932

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