A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved]
Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, a...
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| Format: | Article |
| Language: | English |
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F1000 Research Ltd
2022-07-01
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| Series: | F1000Research |
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| Online Access: | https://f1000research.com/articles/11-552/v2 |
| _version_ | 1798040630898720768 |
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| author | Mulyoto Pangestu Ria Margiana Cennikon Pakpahan |
| author_facet | Mulyoto Pangestu Ria Margiana Cennikon Pakpahan |
| author_sort | Mulyoto Pangestu |
| collection | DOAJ |
| description | Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care. |
| first_indexed | 2024-04-11T22:10:22Z |
| format | Article |
| id | doaj.art-e500f5da889b4fffa7899c4b763f3285 |
| institution | Directory Open Access Journal |
| issn | 2046-1402 |
| language | English |
| last_indexed | 2024-04-11T22:10:22Z |
| publishDate | 2022-07-01 |
| publisher | F1000 Research Ltd |
| record_format | Article |
| series | F1000Research |
| spelling | doaj.art-e500f5da889b4fffa7899c4b763f32852022-12-22T04:00:35ZengF1000 Research LtdF1000Research2046-14022022-07-0111136641A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved]Mulyoto Pangestu0https://orcid.org/0000-0001-5623-3995Ria Margiana1https://orcid.org/0000-0002-6747-0117Cennikon Pakpahan2https://orcid.org/0000-0003-0157-1131Education Program in Reproduction and Development (EPRD), Department of Obstetrics and Gynaecology, Monash Clinical School, Monash University, Clayton, AustraliaDepartment of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, IndonesiaAndrology Study Program, Faculty of Medicine, Universitas Airlangga, Surabaya, IndonesiaBackground: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care.https://f1000research.com/articles/11-552/v2retinoic acid spermatozoa male infertility reproductive health care clinical application stem celleng |
| spellingShingle | Mulyoto Pangestu Ria Margiana Cennikon Pakpahan A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved] F1000Research retinoic acid spermatozoa male infertility reproductive health care clinical application stem cell eng |
| title | A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved] |
| title_full | A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved] |
| title_fullStr | A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved] |
| title_full_unstemmed | A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved] |
| title_short | A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application [version 2; peer review: 2 approved] |
| title_sort | systematic review of retinoic acid in the journey of spermatogonium to spermatozoa from basic to clinical application version 2 peer review 2 approved |
| topic | retinoic acid spermatozoa male infertility reproductive health care clinical application stem cell eng |
| url | https://f1000research.com/articles/11-552/v2 |
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