Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications
Gastric cancer (GC) is one of the most lethal malignancies worldwide. However, the molecular mechanisms underlying gastric carcinogenesis remain largely unknown. Over the past decades, advances in RNA-sequencing techniques have greatly facilitated the identification of various non-coding RNAs (ncRNA...
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Frontiers Media S.A.
2021-11-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2021.732036/full |
| _version_ | 1818692987200208896 |
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| author | Di Chen Shuai Ping Yushuang Xu Mengmeng Wang Xin Jiang Lina Xiong Li Zhang Honglu Yu Zhifan Xiong |
| author_facet | Di Chen Shuai Ping Yushuang Xu Mengmeng Wang Xin Jiang Lina Xiong Li Zhang Honglu Yu Zhifan Xiong |
| author_sort | Di Chen |
| collection | DOAJ |
| description | Gastric cancer (GC) is one of the most lethal malignancies worldwide. However, the molecular mechanisms underlying gastric carcinogenesis remain largely unknown. Over the past decades, advances in RNA-sequencing techniques have greatly facilitated the identification of various non-coding RNAs (ncRNAs) in cancer cells, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Accumulating evidence has revealed that ncRNAs are essential regulators in GC occurrence and development. However, ncRNAs represent an emerging field of cancer research, and their complex functionality remains to be clarified. Considering the lack of viable biomarkers and therapeutic targets in GC, further studies should focus on elucidating the intricate relationships between ncRNAs and GC, which can be translated into clinical practice. In this review, we summarize recent research progress on how ncRNAs modulate the malignant hallmarks of GC, especially in tumor immune escape, drug resistance, and stemness. We also discuss the promising applications of ncRNAs as diagnostic biomarkers and therapeutic targets in GC, aiming to validate their practical value for clinical treatment. |
| first_indexed | 2024-12-17T13:06:31Z |
| format | Article |
| id | doaj.art-e502ce0ab2ea48cc9b004d0249fe88fe |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-12-17T13:06:31Z |
| publishDate | 2021-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-e502ce0ab2ea48cc9b004d0249fe88fe2022-12-21T21:47:15ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2021-11-01910.3389/fcell.2021.732036732036Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical ApplicationsDi Chen0Shuai Ping1Yushuang Xu2Mengmeng Wang3Xin Jiang4Lina Xiong5Li Zhang6Honglu Yu7Zhifan Xiong8Department of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Orthopaedics, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaDepartment of Gastroenterology, Liyuan Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaGastric cancer (GC) is one of the most lethal malignancies worldwide. However, the molecular mechanisms underlying gastric carcinogenesis remain largely unknown. Over the past decades, advances in RNA-sequencing techniques have greatly facilitated the identification of various non-coding RNAs (ncRNAs) in cancer cells, including microRNAs (miRNAs), long non-coding RNAs (lncRNAs), and circular RNAs (circRNAs). Accumulating evidence has revealed that ncRNAs are essential regulators in GC occurrence and development. However, ncRNAs represent an emerging field of cancer research, and their complex functionality remains to be clarified. Considering the lack of viable biomarkers and therapeutic targets in GC, further studies should focus on elucidating the intricate relationships between ncRNAs and GC, which can be translated into clinical practice. In this review, we summarize recent research progress on how ncRNAs modulate the malignant hallmarks of GC, especially in tumor immune escape, drug resistance, and stemness. We also discuss the promising applications of ncRNAs as diagnostic biomarkers and therapeutic targets in GC, aiming to validate their practical value for clinical treatment.https://www.frontiersin.org/articles/10.3389/fcell.2021.732036/fullgastric cancernon-coding RNAsbiological functionsbiomarkertargeted therapy |
| spellingShingle | Di Chen Shuai Ping Yushuang Xu Mengmeng Wang Xin Jiang Lina Xiong Li Zhang Honglu Yu Zhifan Xiong Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications Frontiers in Cell and Developmental Biology gastric cancer non-coding RNAs biological functions biomarker targeted therapy |
| title | Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications |
| title_full | Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications |
| title_fullStr | Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications |
| title_full_unstemmed | Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications |
| title_short | Non-Coding RNAs in Gastric Cancer: From Malignant Hallmarks to Clinical Applications |
| title_sort | non coding rnas in gastric cancer from malignant hallmarks to clinical applications |
| topic | gastric cancer non-coding RNAs biological functions biomarker targeted therapy |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2021.732036/full |
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