Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee
IntroductionAccurately estimating bone perfusion and metabolism using [18F]NaF kinetics from shorter scan times could help address concerns related to patient comfort, motion, and throughput for PET scans. We examined the impact of changing the PET scan duration on the accuracy of [18F]NaF kinetic p...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-11-01
|
| Series: | Frontiers in Nuclear Medicine |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnume.2023.1194961/full |
| _version_ | 1797465334728359936 |
|---|---|
| author | Lauren E. Watkins Lauren E. Watkins Bryan Haddock Ananya Goyal Ananya Goyal Feliks Kogan |
| author_facet | Lauren E. Watkins Lauren E. Watkins Bryan Haddock Ananya Goyal Ananya Goyal Feliks Kogan |
| author_sort | Lauren E. Watkins |
| collection | DOAJ |
| description | IntroductionAccurately estimating bone perfusion and metabolism using [18F]NaF kinetics from shorter scan times could help address concerns related to patient comfort, motion, and throughput for PET scans. We examined the impact of changing the PET scan duration on the accuracy of [18F]NaF kinetic parameters in the knee.MethodsBoth knees of twenty participants with and without osteoarthritis were scanned using a hybrid PET-MRI system (53 ± 13 years, BMI 25.9 ± 4.2 kg/m2, 13 female). Seventeen participants were scanned for 54 ± 2 min, and an additional three participants were scanned for 75 min. Patlak Ki and Hawkins kinetic parameters (Ki, K1, extraction fraction) were assessed using 50- or 75-minutes of scan data as well as for scan durations that were retrospectively shortened. The error of the kinetic uptake parameters was calculated in bone regions throughout the knee.ResultsThe mean error of Patlak Ki, Hawkins Ki, K1, and extraction fraction was less than 10% for scan durations exceeding 30 min and decreased with increasing scan duration.ConclusionsThe length of dynamic data acquisition can be reduced to as short as 30 min while retaining accuracy within the limits of reproducibility of Hawkins kinetic uptake parameters. |
| first_indexed | 2024-03-09T18:20:05Z |
| format | Article |
| id | doaj.art-e50771fa0988428d8583d95a48f8f43a |
| institution | Directory Open Access Journal |
| issn | 2673-8880 |
| language | English |
| last_indexed | 2024-03-09T18:20:05Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nuclear Medicine |
| spelling | doaj.art-e50771fa0988428d8583d95a48f8f43a2023-11-24T08:23:19ZengFrontiers Media S.A.Frontiers in Nuclear Medicine2673-88802023-11-01310.3389/fnume.2023.11949611194961Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the kneeLauren E. Watkins0Lauren E. Watkins1Bryan Haddock2Ananya Goyal3Ananya Goyal4Feliks Kogan5Department of Radiology, Stanford University, Stanford, CA, United StatesDepartment of Imaging Research, Steadman Philippon Research Institute, Vail, CO, United StatesDepartment of Clinical Physiology, Nuclear Medicine and PET, Rigshospitalet, Copenhagen University Hospital, Copenhagen, DenmarkDepartment of Radiology, Stanford University, Stanford, CA, United StatesDepartment of Bioengineering, Stanford University, Stanford, CA, United StatesDepartment of Radiology, Stanford University, Stanford, CA, United StatesIntroductionAccurately estimating bone perfusion and metabolism using [18F]NaF kinetics from shorter scan times could help address concerns related to patient comfort, motion, and throughput for PET scans. We examined the impact of changing the PET scan duration on the accuracy of [18F]NaF kinetic parameters in the knee.MethodsBoth knees of twenty participants with and without osteoarthritis were scanned using a hybrid PET-MRI system (53 ± 13 years, BMI 25.9 ± 4.2 kg/m2, 13 female). Seventeen participants were scanned for 54 ± 2 min, and an additional three participants were scanned for 75 min. Patlak Ki and Hawkins kinetic parameters (Ki, K1, extraction fraction) were assessed using 50- or 75-minutes of scan data as well as for scan durations that were retrospectively shortened. The error of the kinetic uptake parameters was calculated in bone regions throughout the knee.ResultsThe mean error of Patlak Ki, Hawkins Ki, K1, and extraction fraction was less than 10% for scan durations exceeding 30 min and decreased with increasing scan duration.ConclusionsThe length of dynamic data acquisition can be reduced to as short as 30 min while retaining accuracy within the limits of reproducibility of Hawkins kinetic uptake parameters.https://www.frontiersin.org/articles/10.3389/fnume.2023.1194961/full[18F]NaF PETscan durationHawkins modelosteoarthritiskinetic uptake parameters |
| spellingShingle | Lauren E. Watkins Lauren E. Watkins Bryan Haddock Ananya Goyal Ananya Goyal Feliks Kogan Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee Frontiers in Nuclear Medicine [18F]NaF PET scan duration Hawkins model osteoarthritis kinetic uptake parameters |
| title | Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee |
| title_full | Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee |
| title_fullStr | Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee |
| title_full_unstemmed | Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee |
| title_short | Effects of dynamic [18F]NaF PET scan duration on kinetic uptake parameters in the knee |
| title_sort | effects of dynamic 18f naf pet scan duration on kinetic uptake parameters in the knee |
| topic | [18F]NaF PET scan duration Hawkins model osteoarthritis kinetic uptake parameters |
| url | https://www.frontiersin.org/articles/10.3389/fnume.2023.1194961/full |
| work_keys_str_mv | AT laurenewatkins effectsofdynamic18fnafpetscandurationonkineticuptakeparametersintheknee AT laurenewatkins effectsofdynamic18fnafpetscandurationonkineticuptakeparametersintheknee AT bryanhaddock effectsofdynamic18fnafpetscandurationonkineticuptakeparametersintheknee AT ananyagoyal effectsofdynamic18fnafpetscandurationonkineticuptakeparametersintheknee AT ananyagoyal effectsofdynamic18fnafpetscandurationonkineticuptakeparametersintheknee AT felikskogan effectsofdynamic18fnafpetscandurationonkineticuptakeparametersintheknee |