Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span
Compared are the gene sequences of the global phoP/phoQ and rovA transcription regulators in original Yersinia pestis strains of different subtypes. Detected is overall identity of the sequenced phoQ fragment and high conservatism of the rovA gene. All the plague agent strains belonging to the main...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | Russian |
| Published: |
Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”
2012-04-01
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| Series: | Проблемы особо опасных инфекций |
| Subjects: | |
| Online Access: | https://journal.microbe.ru/jour/article/view/789 |
| _version_ | 1797220974248067072 |
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| author | G. A. Eroshenko E. I. Koshel' G. N. Odinokov N. Yu. Shavina Ya. M. Krasnov N. P. Guseva V. V. Kutyrev |
| author_facet | G. A. Eroshenko E. I. Koshel' G. N. Odinokov N. Yu. Shavina Ya. M. Krasnov N. P. Guseva V. V. Kutyrev |
| author_sort | G. A. Eroshenko |
| collection | DOAJ |
| description | Compared are the gene sequences of the global phoP/phoQ and rovA transcription regulators in original Yersinia pestis strains of different subtypes. Detected is overall identity of the sequenced phoQ fragment and high conservatism of the rovA gene. All the plague agent strains belonging to the main subspecies have a missense mutation in phoP gene. It is a substitution of a single nucleotide G→A in the position 643 from the beginning of the gene, which causes amino-acid residue shift Gly→Ser in the position 215 in polypeptide chain of the PhopP protein, and, is a possible cause of alteration of the PhoP transcription activity in Yersinia pestis strains belonging to the main subspecies. |
| first_indexed | 2024-03-08T13:44:54Z |
| format | Article |
| id | doaj.art-e50a25a9bf4a41a7b618ebc19ae5cc68 |
| institution | Directory Open Access Journal |
| issn | 0370-1069 2658-719X |
| language | Russian |
| last_indexed | 2024-04-24T12:58:04Z |
| publishDate | 2012-04-01 |
| publisher | Federal Government Health Institution, Russian Research Anti-Plague Institute “Microbe” |
| record_format | Article |
| series | Проблемы особо опасных инфекций |
| spelling | doaj.art-e50a25a9bf4a41a7b618ebc19ae5cc682024-04-05T16:47:08ZrusFederal Government Health Institution, Russian Research Anti-Plague Institute “Microbe”Проблемы особо опасных инфекций0370-10692658-719X2012-04-0102(112)252810.21055/0370-1069-2012-2(112)-25-28773Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life SpanG. A. Eroshenko0E. I. Koshel'1G. N. Odinokov2N. Yu. Shavina3Ya. M. Krasnov4N. P. Guseva5V. V. Kutyrev6Russian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeRussian Research Anti-Plague Institute MicrobeCompared are the gene sequences of the global phoP/phoQ and rovA transcription regulators in original Yersinia pestis strains of different subtypes. Detected is overall identity of the sequenced phoQ fragment and high conservatism of the rovA gene. All the plague agent strains belonging to the main subspecies have a missense mutation in phoP gene. It is a substitution of a single nucleotide G→A in the position 643 from the beginning of the gene, which causes amino-acid residue shift Gly→Ser in the position 215 in polypeptide chain of the PhopP protein, and, is a possible cause of alteration of the PhoP transcription activity in Yersinia pestis strains belonging to the main subspecies.https://journal.microbe.ru/jour/article/view/789plague agentregulatory genesvariability of the nucleotide sequences |
| spellingShingle | G. A. Eroshenko E. I. Koshel' G. N. Odinokov N. Yu. Shavina Ya. M. Krasnov N. P. Guseva V. V. Kutyrev Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span Проблемы особо опасных инфекций plague agent regulatory genes variability of the nucleotide sequences |
| title | Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span |
| title_full | Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span |
| title_fullStr | Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span |
| title_full_unstemmed | Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span |
| title_short | Variability of <i>phoP/phoQ</i> and <i>rovA</i> Genes Sequences - Global Regulators of the Plague Agent Life Span |
| title_sort | variability of i phop phoq i and i rova i genes sequences global regulators of the plague agent life span |
| topic | plague agent regulatory genes variability of the nucleotide sequences |
| url | https://journal.microbe.ru/jour/article/view/789 |
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