Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)
Background: Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxi...
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| Format: | Article |
| Language: | English |
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Society of Medical Biochemists of Serbia, Belgrade
2021-01-01
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| Series: | Journal of Medical Biochemistry |
| Subjects: | |
| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2021/1452-82582103286A.pdf |
| _version_ | 1818741586758991872 |
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| author | Aladağ Nesim Asoğlu Ramazan Ozdemir Mahmut Asoğlu Emin Derin Atabey Rukiye Demir Canan Demir Halit |
| author_facet | Aladağ Nesim Asoğlu Ramazan Ozdemir Mahmut Asoğlu Emin Derin Atabey Rukiye Demir Canan Demir Halit |
| author_sort | Aladağ Nesim |
| collection | DOAJ |
| description | Background: Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI. Methods: The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography. Results: Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p<0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p<0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p<0.001 MDA vs catalase; r = -0.821 p<0.001 SOD vs catalase). Conclusions: Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels of MDA and IMA and decreased levels of SOD and catalase. |
| first_indexed | 2024-12-18T01:58:59Z |
| format | Article |
| id | doaj.art-e50b61966a514268bf9f43c0c776a547 |
| institution | Directory Open Access Journal |
| issn | 1452-8258 1452-8266 |
| language | English |
| last_indexed | 2024-12-18T01:58:59Z |
| publishDate | 2021-01-01 |
| publisher | Society of Medical Biochemists of Serbia, Belgrade |
| record_format | Article |
| series | Journal of Medical Biochemistry |
| spelling | doaj.art-e50b61966a514268bf9f43c0c776a5472022-12-21T21:24:50ZengSociety of Medical Biochemists of Serbia, BelgradeJournal of Medical Biochemistry1452-82581452-82662021-01-0140328629410.5937/jomb0-288791452-82582103286AOxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI)Aladağ Nesim0https://orcid.org/0000-0003-2346-1152Asoğlu Ramazan1Ozdemir Mahmut2Asoğlu Emin3Derin Atabey Rukiye4Demir Canan5Demir Halit6Van Yuzuncu Yil University, Faculty of Medicine, Department of Cardiology, Van, TurkeyAdıyaman University, Training and Research Hospital, Cardiology Department, Adıyaman, TurkeyBayrampa a Kolan Hospital, Cardiology Department, Istanbul, TurkeyMardin Community Hospital, Cardiology Department, Mardin, TurkeyUniversity of Health Sciences, Van Training and Research Hospital, Cardiovascular Surgery Department, Van, TurkeyVan Yüzüncü Yıl University, Vocational School of Health Services, Van, TurkeyVan Yüzüncü Yıl University, Department of Biochemistry, Van, TurkeyBackground: Coronary ischemia can lead to myocardial damage and necrosis. The pathogenesis of cardiovascular diseases often includes increased oxidative stress and decreased antioxidant defense. The study aimed to assess levels of ischemia modified albumin (IMA), malondialdehyde acid (MDA), superoxide dismutase (SOD), and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI. Methods: The present study prospectively included 50 STEMI patients, 55 NSTEMI patients, and 55 healthy subjects. Only patients who were recently diagnosed with STEMI or NSTEMI were included in this study. IMA, MDA, SOD, and catalase activities were measured spectrophotometrically. Significant coronary artery lesions were determined by angiography. Results: Patients with ACS had significantly greater IMA and MDA values than the healthy controls (p<0.001). Besides, patients with STEMI had IMA levels that were significantly greater than those of the patients with NSTEMI (p<0.001), while the reverse was true for MDA levels (p<0.001). The healthy controls had the highest levels of SOD and catalase levels, followed by patients with STEMI and patients with NSTEMI, respectively (p<0.001). There was a significant negative correlation among MDA and SOD with catalase levels (r = -0.771 p<0.001 MDA vs catalase; r = -0.821 p<0.001 SOD vs catalase). Conclusions: Data obtained in this study reveals that compared to healthy controls, STEMI and NSTEMI patients had increased levels of MDA and IMA and decreased levels of SOD and catalase.https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2021/1452-82582103286A.pdfsteminstemiischemia modified albuminmalondialdehyde acidsuperoxide dismutasecatalase |
| spellingShingle | Aladağ Nesim Asoğlu Ramazan Ozdemir Mahmut Asoğlu Emin Derin Atabey Rukiye Demir Canan Demir Halit Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) Journal of Medical Biochemistry stemi nstemi ischemia modified albumin malondialdehyde acid superoxide dismutase catalase |
| title | Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) |
| title_full | Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) |
| title_fullStr | Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) |
| title_full_unstemmed | Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) |
| title_short | Oxidants and antioxidants in myocardial infarction (MI): Investigation of ischemia modified albumin, malondialdehyde, superoxide dismutase and catalase in individuals diagnosed with ST elevated myocardial infarction (STEMI) and non-STEMI (NSTEMI) |
| title_sort | oxidants and antioxidants in myocardial infarction mi investigation of ischemia modified albumin malondialdehyde superoxide dismutase and catalase in individuals diagnosed with st elevated myocardial infarction stemi and non stemi nstemi |
| topic | stemi nstemi ischemia modified albumin malondialdehyde acid superoxide dismutase catalase |
| url | https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2021/1452-82582103286A.pdf |
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