The role of mediodorsal thalamus in temporal differentiation of reward-guided actions
The mediodorsal thalamus (MD) is a crucial component of the neural network involved in the learning and generation of goal-directed actions. A series of experiments reported here examined the contributions of MD to the temporal differentiation of reward-guided actions. In Experiment 1, we trained...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2010-05-01
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| Series: | Frontiers in Integrative Neuroscience |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fnint.2010.00014/full |
| _version_ | 1811301721340641280 |
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| author | Chunxiu Yu Jay Gupta Henry H Yin |
| author_facet | Chunxiu Yu Jay Gupta Henry H Yin |
| author_sort | Chunxiu Yu |
| collection | DOAJ |
| description | The mediodorsal thalamus (MD) is a crucial component of the neural network involved in the learning and generation of goal-directed actions. A series of experiments reported here examined the contributions of MD to the temporal differentiation of reward-guided actions. In Experiment 1, we trained rats on a discrete-trial, fixed-criterion temporal differentiation task, in which only lever presses exceeding a threshold duration value were rewarded. Pre-training MD lesions impaired temporal differentiation of action duration, by increasing the dispersion of the duration distribution. Post-training MD lesions also impaired differentiation, but by reducing the average emitted press durations, thus shifting the distribution without increasing the dispersion. In Experiment 2, we trained rats to space their lever pressing above criterion inter-press-intervals in order to earn rewards. Both pre-training and post-training MD lesions impaired the differentiation of inter-press-intervals. These results show that MD plays an important role in the acquisition and expression of action differentiation. |
| first_indexed | 2024-04-13T07:15:01Z |
| format | Article |
| id | doaj.art-e50bb04de086450eb1f0b137a93e5273 |
| institution | Directory Open Access Journal |
| issn | 1662-5145 |
| language | English |
| last_indexed | 2024-04-13T07:15:01Z |
| publishDate | 2010-05-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Integrative Neuroscience |
| spelling | doaj.art-e50bb04de086450eb1f0b137a93e52732022-12-22T02:56:47ZengFrontiers Media S.A.Frontiers in Integrative Neuroscience1662-51452010-05-01410.3389/fnint.2010.000141720The role of mediodorsal thalamus in temporal differentiation of reward-guided actionsChunxiu Yu0Jay Gupta1Henry H Yin2Duke UniversityDuke UniversityDuke UniversityThe mediodorsal thalamus (MD) is a crucial component of the neural network involved in the learning and generation of goal-directed actions. A series of experiments reported here examined the contributions of MD to the temporal differentiation of reward-guided actions. In Experiment 1, we trained rats on a discrete-trial, fixed-criterion temporal differentiation task, in which only lever presses exceeding a threshold duration value were rewarded. Pre-training MD lesions impaired temporal differentiation of action duration, by increasing the dispersion of the duration distribution. Post-training MD lesions also impaired differentiation, but by reducing the average emitted press durations, thus shifting the distribution without increasing the dispersion. In Experiment 2, we trained rats to space their lever pressing above criterion inter-press-intervals in order to earn rewards. Both pre-training and post-training MD lesions impaired the differentiation of inter-press-intervals. These results show that MD plays an important role in the acquisition and expression of action differentiation.http://journal.frontiersin.org/Journal/10.3389/fnint.2010.00014/fullmediodorsal thalamusRewardactiondevaluationdifferentiationLearning |
| spellingShingle | Chunxiu Yu Jay Gupta Henry H Yin The role of mediodorsal thalamus in temporal differentiation of reward-guided actions Frontiers in Integrative Neuroscience mediodorsal thalamus Reward action devaluation differentiation Learning |
| title | The role of mediodorsal thalamus in temporal differentiation of reward-guided actions |
| title_full | The role of mediodorsal thalamus in temporal differentiation of reward-guided actions |
| title_fullStr | The role of mediodorsal thalamus in temporal differentiation of reward-guided actions |
| title_full_unstemmed | The role of mediodorsal thalamus in temporal differentiation of reward-guided actions |
| title_short | The role of mediodorsal thalamus in temporal differentiation of reward-guided actions |
| title_sort | role of mediodorsal thalamus in temporal differentiation of reward guided actions |
| topic | mediodorsal thalamus Reward action devaluation differentiation Learning |
| url | http://journal.frontiersin.org/Journal/10.3389/fnint.2010.00014/full |
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