MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis

MCPIP1 Enhances TNF-α-Mediated Apoptosis through Downregulation of the NF-κB/cFLIP Axis

Monocyte chemoattractant protein-1-induced protein 1 (MCPIP1) is rapidly produced under proinflammatory stimuli, thereby feeding back to downregulate excessive inflammation. In this study, we used the stable, inducible expressions of wild-type (WT) MCPIP1 and an MCPIP1-D141N mutant in T-REx-293 cell...

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Bibliographic Details
Main Authors: Fat-Moon Suk, Chi-Ching Chang, Pei-Chi Sun, Wei-Ting Ke, Chia-Chen Chung, Kun-Lin Lee, Tze-Sian Chan, Yu-Chih Liang
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Biology
Subjects:
MCPIP1
TNF-α
apoptosis
caspase-1
importin
Online Access:https://www.mdpi.com/2079-7737/10/7/655

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