Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study
Background and aimsThe progressive and generalized loss of skeletal muscle mass, strength and physical function is defined as sarcopenia. Sarcopenia is closely related to the prognosis of patients. Accurate diagnosis and adequate management of sarcopenia are crucial. The psoas muscle mass index take...
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Frontiers Media S.A.
2022-12-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2022.1033831/full |
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| author | Ming Kong Ning Lin Lili Wang Nan Geng Manman Xu Shanshan Li Wenyan Song Ying Zhou Yuetong Piao Zuoqing Han Rong Guo Chao Yang Nan Luo Zhong Wang Quanxiao Xu Daimeng Shi Wanchun Qiu Junfeng Li Eddie C. Cheung Eddie C. Cheung Lei Ma Yu Chen Zhongping Duan |
| author_facet | Ming Kong Ning Lin Lili Wang Nan Geng Manman Xu Shanshan Li Wenyan Song Ying Zhou Yuetong Piao Zuoqing Han Rong Guo Chao Yang Nan Luo Zhong Wang Quanxiao Xu Daimeng Shi Wanchun Qiu Junfeng Li Eddie C. Cheung Eddie C. Cheung Lei Ma Yu Chen Zhongping Duan |
| author_sort | Ming Kong |
| collection | DOAJ |
| description | Background and aimsThe progressive and generalized loss of skeletal muscle mass, strength and physical function is defined as sarcopenia. Sarcopenia is closely related to the prognosis of patients. Accurate diagnosis and adequate management of sarcopenia are crucial. The psoas muscle mass index taken at the third lumbar vertebra (L3-PMI, cm2/m2) is one of the established methods for evaluating skeletal muscle mass. However, the cutoff values of L3-PMI for diagnosis of sarcopenia are not yet to be clarified in Asian populations. We attempted to establish reference values for low L3-PMI that would be suitable for defining sarcopenia in the Northern Chinese population.MethodsThis was a retrospective, multicenter cross-sectional study. A search of abdominal CT imaging reports was conducted in four representative cities in northern China. Transverse CT images were measured using the analysis software Slice-O-Matic. Low psoas muscle index was defined as the 5th percentile or mean-2SD of the study group.Results1,787 healthy individuals in the study were grouped by age. The sex and number of people in each group were similar. L3-PMI had a negative linear correlation with age, and a strong correlation with the skeletal muscle index taken at the third lumbar vertebrae (L3-SMI, cm2/m2). The L3-PMI reference values in males were 5.41 cm2/m2 for 20–29 years, 4.71 cm2/m2 for 30–39 years, 4.65 cm2/m2 for 40–49 years, 4.10 cm2/m2 for 50–59 years and 3.68 cm2/m2 for over 60 years by using 5th percentile threshold. Similarly, the reference values in females were 3.32, 3.40, 3.18, 2.91, and 2.62 cm2/m2. When using mean-2SD as the reference, the values for each age group were 4.57, 4.16, 4.03, 3.37, and 2.87 cm2/m2 for males and 2.79, 2.70, 2.50, 2.30, and 2.26 cm2/m2 for females, respectively.ConclusionWe defined the reference values of age-specific low skeletal muscle mass when simply evaluated by L3-PMI. Further studies about the association of sarcopenia using these reference values with certain clinical outcomes or diseases are needed. |
| first_indexed | 2024-04-10T20:44:12Z |
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| spelling | doaj.art-e50cb9a637d54da6a6613802133c317c2023-01-24T11:47:08ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2022-12-01910.3389/fnut.2022.10338311033831Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter studyMing Kong0Ning Lin1Lili Wang2Nan Geng3Manman Xu4Shanshan Li5Wenyan Song6Ying Zhou7Yuetong Piao8Zuoqing Han9Rong Guo10Chao Yang11Nan Luo12Zhong Wang13Quanxiao Xu14Daimeng Shi15Wanchun Qiu16Junfeng Li17Eddie C. Cheung18Eddie C. Cheung19Lei Ma20Yu Chen21Zhongping Duan22Beijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, The First Hospital of Lanzhou University, Lanzhou, ChinaBeijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Radiology, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaDepartment of Gastroenterology and Hepatology, The Chinese People’s Liberation Army Rocket Force Characteristic Medical Center, Postgraduate Training Base of Jinzhou Medical University, Beijing, ChinaDepartment of Infection, Dalian Medical University, Dalian, ChinaDepartment of Infection, Dalian Medical University, Dalian, ChinaDepartment of Infection, Dalian Medical University, Dalian, ChinaDepartment of Radiology, The Second Hospital of Dalian Medical University, Dalian, ChinaDepartment of Infection, The Second Hospital of Dalian Medical University, Dalian, ChinaDiagnosis and Treatment Center of Hepatobiliary Diseases, Nanyang First People’s Hospital, Nanyang, ChinaDiagnosis and Treatment Center of Hepatobiliary Diseases, Nanyang First People’s Hospital, Nanyang, ChinaDiagnosis and Treatment Center of Hepatobiliary Diseases, Nanyang First People’s Hospital, Nanyang, ChinaDepartment of Infection, The First Clinical Medical School of Lanzhou University, Lanzhou, China0Department of Infectious Diseases, Institute of Infectious Diseases, The First Hospital of Lanzhou University, Lanzhou, China1Division of Gastroenterology, School of Medicine, University of California, Davis, Davis, CA, United States2Center for Digestive Disease, The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen, ChinaDiagnosis and Treatment Center of Hepatobiliary Diseases, Nanyang First People’s Hospital, Nanyang, ChinaBeijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBeijing Municipal Key Laboratory of Liver Failure and Artificial Liver Treatment Research, Fourth Department of Liver Disease, Beijing Youan Hospital, Capital Medical University, Beijing, ChinaBackground and aimsThe progressive and generalized loss of skeletal muscle mass, strength and physical function is defined as sarcopenia. Sarcopenia is closely related to the prognosis of patients. Accurate diagnosis and adequate management of sarcopenia are crucial. The psoas muscle mass index taken at the third lumbar vertebra (L3-PMI, cm2/m2) is one of the established methods for evaluating skeletal muscle mass. However, the cutoff values of L3-PMI for diagnosis of sarcopenia are not yet to be clarified in Asian populations. We attempted to establish reference values for low L3-PMI that would be suitable for defining sarcopenia in the Northern Chinese population.MethodsThis was a retrospective, multicenter cross-sectional study. A search of abdominal CT imaging reports was conducted in four representative cities in northern China. Transverse CT images were measured using the analysis software Slice-O-Matic. Low psoas muscle index was defined as the 5th percentile or mean-2SD of the study group.Results1,787 healthy individuals in the study were grouped by age. The sex and number of people in each group were similar. L3-PMI had a negative linear correlation with age, and a strong correlation with the skeletal muscle index taken at the third lumbar vertebrae (L3-SMI, cm2/m2). The L3-PMI reference values in males were 5.41 cm2/m2 for 20–29 years, 4.71 cm2/m2 for 30–39 years, 4.65 cm2/m2 for 40–49 years, 4.10 cm2/m2 for 50–59 years and 3.68 cm2/m2 for over 60 years by using 5th percentile threshold. Similarly, the reference values in females were 3.32, 3.40, 3.18, 2.91, and 2.62 cm2/m2. When using mean-2SD as the reference, the values for each age group were 4.57, 4.16, 4.03, 3.37, and 2.87 cm2/m2 for males and 2.79, 2.70, 2.50, 2.30, and 2.26 cm2/m2 for females, respectively.ConclusionWe defined the reference values of age-specific low skeletal muscle mass when simply evaluated by L3-PMI. Further studies about the association of sarcopenia using these reference values with certain clinical outcomes or diseases are needed.https://www.frontiersin.org/articles/10.3389/fnut.2022.1033831/fullskeletal muscle masssarcopeniacomputed tomographylumbar 3 vertebrareference valueshealthy adults |
| spellingShingle | Ming Kong Ning Lin Lili Wang Nan Geng Manman Xu Shanshan Li Wenyan Song Ying Zhou Yuetong Piao Zuoqing Han Rong Guo Chao Yang Nan Luo Zhong Wang Quanxiao Xu Daimeng Shi Wanchun Qiu Junfeng Li Eddie C. Cheung Eddie C. Cheung Lei Ma Yu Chen Zhongping Duan Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study Frontiers in Nutrition skeletal muscle mass sarcopenia computed tomography lumbar 3 vertebra reference values healthy adults |
| title | Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study |
| title_full | Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study |
| title_fullStr | Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study |
| title_full_unstemmed | Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study |
| title_short | Age-specific reference values for low psoas muscle index at the L3 vertebra level in healthy populations: A multicenter study |
| title_sort | age specific reference values for low psoas muscle index at the l3 vertebra level in healthy populations a multicenter study |
| topic | skeletal muscle mass sarcopenia computed tomography lumbar 3 vertebra reference values healthy adults |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2022.1033831/full |
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