Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
Increased activity of dipeptidyl peptidase IV (DPP-IV) was reported earlier in patients with different types of mucopolysaccharidoses. DPP-IV (also known as CD26 lymphocyte T surface antigen) is a transmembrane protein showing protease activity. This enzyme displays various functions in the organism...
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MDPI AG
2021-02-01
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| Series: | Diagnostics |
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| Online Access: | https://www.mdpi.com/2075-4418/11/2/320 |
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| author | Agnieszka Ługowska Galina Baydakova Alex Ilyushkina Ekaterina Zakharova Hanna Mierzewska Krystyna Szymańska Jolanta Wierzba Jolanta Kubalska Ałła Graban Tomasz Kmieć Barbara Perkowska-Sumiła Anna Tylki-Szymańska Małgorzata Bednarska-Makaruk |
| author_facet | Agnieszka Ługowska Galina Baydakova Alex Ilyushkina Ekaterina Zakharova Hanna Mierzewska Krystyna Szymańska Jolanta Wierzba Jolanta Kubalska Ałła Graban Tomasz Kmieć Barbara Perkowska-Sumiła Anna Tylki-Szymańska Małgorzata Bednarska-Makaruk |
| author_sort | Agnieszka Ługowska |
| collection | DOAJ |
| description | Increased activity of dipeptidyl peptidase IV (DPP-IV) was reported earlier in patients with different types of mucopolysaccharidoses. DPP-IV (also known as CD26 lymphocyte T surface antigen) is a transmembrane protein showing protease activity. This enzyme displays various functions in the organism and plays an important role in multiple processes like glucose metabolism, nociception, cell-adhesion, psychoneuroendocrine regulation, immune response and cardiovascular adaptation. In order to evaluate DPP-IV in lysosomal storage diseases (LSD), we examined its activity in plasma samples from 307 patients affected with 24 different LSDs and in 75 control persons. Our results revealed elevated DPP-IV activity especially in individuals affected with mucolipidosis II/III, alpha-mannosidosis, and mucopolysaccharidoses types III, II, and I (<i>p</i> < 0.05). In other LSDs the DPP-IV activity was still significantly increased, but to a lesser extent. In patients with Gaucher disease, ceroid lipofuscinosis type 1 (CLN1), Niemann–Pick disease type C and A, Krabbe and Pompe diseases, gangliosidosis GM2 and metachromatic leukodystrophy discreet or no changes in DPP-IV activity were observed. DPP-IV may serve as a first-tier diagnostic procedure or additional biochemical analysis in recognizing patients with some LSDs. DPP-IV may become an object of basic research for a better understanding of LSDs. |
| first_indexed | 2024-03-09T00:50:01Z |
| format | Article |
| id | doaj.art-e50ce5218c0644baaf48e583eb8bd269 |
| institution | Directory Open Access Journal |
| issn | 2075-4418 |
| language | English |
| last_indexed | 2024-03-09T00:50:01Z |
| publishDate | 2021-02-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Diagnostics |
| spelling | doaj.art-e50ce5218c0644baaf48e583eb8bd2692023-12-11T17:18:17ZengMDPI AGDiagnostics2075-44182021-02-0111232010.3390/diagnostics11020320Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal DiseasesAgnieszka Ługowska0Galina Baydakova1Alex Ilyushkina2Ekaterina Zakharova3Hanna Mierzewska4Krystyna Szymańska5Jolanta Wierzba6Jolanta Kubalska7Ałła Graban8Tomasz Kmieć9Barbara Perkowska-Sumiła10Anna Tylki-Szymańska11Małgorzata Bednarska-Makaruk12Department of Genetics, Institute of Psychiatry and Neurology, 02-957 Warsaw, PolandResearch Centre for Medical Genetics, Federal State Budgetary Institution, 115478 Moscow, RussiaResearch Centre for Medical Genetics, Federal State Budgetary Institution, 115478 Moscow, RussiaResearch Centre for Medical Genetics, Federal State Budgetary Institution, 115478 Moscow, RussiaDepartment of Child and Adolescent Neurology, Institute of Mother and Child, 01-211 Warsaw, PolandMossakowski Medical Research Center, Department of Experimental and Clinical Neuropathology, Polish Academy of Sciences, 02-106 Warsaw, PolandDepartment of Internal and Pediatric Nursing, Institute of Nursing and Midwifery, Medical University of Gdańsk, 80-210 Gdańsk, PolandDepartment of Genetics, Institute of Psychiatry and Neurology, 02-957 Warsaw, Poland1st Department of Neurology, Institute of Psychiatry and Neurology, 02-957 Warsaw, PolandDepartment of Neurology and Epileptology, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatrics, Nutrition and Metabolic Diseases, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Pediatrics, Nutrition and Metabolic Diseases, The Children’s Memorial Health Institute, 04-730 Warsaw, PolandDepartment of Genetics, Institute of Psychiatry and Neurology, 02-957 Warsaw, PolandIncreased activity of dipeptidyl peptidase IV (DPP-IV) was reported earlier in patients with different types of mucopolysaccharidoses. DPP-IV (also known as CD26 lymphocyte T surface antigen) is a transmembrane protein showing protease activity. This enzyme displays various functions in the organism and plays an important role in multiple processes like glucose metabolism, nociception, cell-adhesion, psychoneuroendocrine regulation, immune response and cardiovascular adaptation. In order to evaluate DPP-IV in lysosomal storage diseases (LSD), we examined its activity in plasma samples from 307 patients affected with 24 different LSDs and in 75 control persons. Our results revealed elevated DPP-IV activity especially in individuals affected with mucolipidosis II/III, alpha-mannosidosis, and mucopolysaccharidoses types III, II, and I (<i>p</i> < 0.05). In other LSDs the DPP-IV activity was still significantly increased, but to a lesser extent. In patients with Gaucher disease, ceroid lipofuscinosis type 1 (CLN1), Niemann–Pick disease type C and A, Krabbe and Pompe diseases, gangliosidosis GM2 and metachromatic leukodystrophy discreet or no changes in DPP-IV activity were observed. DPP-IV may serve as a first-tier diagnostic procedure or additional biochemical analysis in recognizing patients with some LSDs. DPP-IV may become an object of basic research for a better understanding of LSDs.https://www.mdpi.com/2075-4418/11/2/320DPP-IVlysosomal diseasesmucolipidosis II/IIImucopolysaccharidosesalpha-mannosidosisdiagnosis |
| spellingShingle | Agnieszka Ługowska Galina Baydakova Alex Ilyushkina Ekaterina Zakharova Hanna Mierzewska Krystyna Szymańska Jolanta Wierzba Jolanta Kubalska Ałła Graban Tomasz Kmieć Barbara Perkowska-Sumiła Anna Tylki-Szymańska Małgorzata Bednarska-Makaruk Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases Diagnostics DPP-IV lysosomal diseases mucolipidosis II/III mucopolysaccharidoses alpha-mannosidosis diagnosis |
| title | Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases |
| title_full | Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases |
| title_fullStr | Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases |
| title_full_unstemmed | Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases |
| title_short | Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases |
| title_sort | elevated dipeptidyl peptidase iv dpp iv activity in plasma from patients with various lysosomal diseases |
| topic | DPP-IV lysosomal diseases mucolipidosis II/III mucopolysaccharidoses alpha-mannosidosis diagnosis |
| url | https://www.mdpi.com/2075-4418/11/2/320 |
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