Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.

Thrombopoietin is required for full phenotype expression in a JAK2V617F transgenic mouse model of polycythemia vera.

The myeloproliferative neoplasms, polycythemia vera, essential thrombocytosis and primary myelofibrosis are hematopoietic stem cell disorders and share driver mutations that either directly activate the thrombopoietin receptor, MPL, or activate it indirectly through gain-of-function mutations in the...

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Detalles Bibliográficos
Autores principales: Jerry L Spivak, Akil Merchant, Donna M Williams, Ophelia Rogers, Wanke Zhao, Amy Duffield, Linda S Resar, Alison R Moliterno, Zhizhuang J Zhao
Formato: Artículo
Lenguaje:English
Publicado: Public Library of Science (PLoS) 2020-01-01
Colección:PLoS ONE
Acceso en línea:https://doi.org/10.1371/journal.pone.0232801

Internet

https://doi.org/10.1371/journal.pone.0232801

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