Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen
Abstract PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%). We conducted a retrospective study to determine the safety of re‐c...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-02-01
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| Series: | eJHaem |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/jha2.607 |
| _version_ | 1827318965552021504 |
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| author | Ibrahim Al Nabhani Claire Andrews Jad Sibai Eshetu Atenafu Taylor Young Steven M. Chan Vikas Gupta Dawn Maze Aaron D. Schimmer Andre C. Schuh Karen Yee Hassan Sibai |
| author_facet | Ibrahim Al Nabhani Claire Andrews Jad Sibai Eshetu Atenafu Taylor Young Steven M. Chan Vikas Gupta Dawn Maze Aaron D. Schimmer Andre C. Schuh Karen Yee Hassan Sibai |
| author_sort | Ibrahim Al Nabhani |
| collection | DOAJ |
| description | Abstract PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%). We conducted a retrospective study to determine the safety of re‐challenging adult patients with PEG‐asparaginase after experiencing an episode of severe hypertriglyceridemia (>1000 mg/dl or 11.4 mmol/L). The incidence of hypertriglyceridemia associated with PEG‐asparaginase in adult patients was high (67.5%). Therefore, checking TGs at baseline and monitoring levels while receiving PEG‐asparaginase need to be considered and studied in prospective studies. However, in patients with hypertriglyceridemia not complicated by acute pancreatitis, re‐challenging is safe once TG levels normalize. |
| first_indexed | 2024-03-12T14:07:10Z |
| format | Article |
| id | doaj.art-e50e7e9e08b74513abd28ce4a7d9068c |
| institution | Directory Open Access Journal |
| issn | 2688-6146 |
| language | English |
| last_indexed | 2024-04-25T00:10:40Z |
| publishDate | 2023-02-01 |
| publisher | Wiley |
| record_format | Article |
| series | eJHaem |
| spelling | doaj.art-e50e7e9e08b74513abd28ce4a7d9068c2024-03-13T13:30:48ZengWileyeJHaem2688-61462023-02-014123223510.1002/jha2.607Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimenIbrahim Al Nabhani0Claire Andrews1Jad Sibai2Eshetu Atenafu3Taylor Young4Steven M. Chan5Vikas Gupta6Dawn Maze7Aaron D. Schimmer8Andre C. Schuh9Karen Yee10Hassan Sibai11Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaDivision of Medical Oncology and Hematology, Princess Margaret Cancer Centre University Health Network Toronto Ontario CanadaAbstract PEG‐asparaginase is used as a treatment for Philadelphia‐negative acute lymphoblastic leukemia. In pediatric studies, triglycerides (TGs) were affected more by PEG‐asparaginase than by native L‐asparaginase (10.0% vs. 5.5%). We conducted a retrospective study to determine the safety of re‐challenging adult patients with PEG‐asparaginase after experiencing an episode of severe hypertriglyceridemia (>1000 mg/dl or 11.4 mmol/L). The incidence of hypertriglyceridemia associated with PEG‐asparaginase in adult patients was high (67.5%). Therefore, checking TGs at baseline and monitoring levels while receiving PEG‐asparaginase need to be considered and studied in prospective studies. However, in patients with hypertriglyceridemia not complicated by acute pancreatitis, re‐challenging is safe once TG levels normalize.https://doi.org/10.1002/jha2.607acute lymphoblastic leukemiaacute pancreatitishypertriglyceridemiaPEG‐asparaginasetoxicity |
| spellingShingle | Ibrahim Al Nabhani Claire Andrews Jad Sibai Eshetu Atenafu Taylor Young Steven M. Chan Vikas Gupta Dawn Maze Aaron D. Schimmer Andre C. Schuh Karen Yee Hassan Sibai Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen eJHaem acute lymphoblastic leukemia acute pancreatitis hypertriglyceridemia PEG‐asparaginase toxicity |
| title | Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen |
| title_full | Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen |
| title_fullStr | Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen |
| title_full_unstemmed | Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen |
| title_short | Safety of re‐challenging adults with acute lymphoblastic leukemia with PEG‐asparaginase‐induced severe hypertriglyceridemia when treated with a pediatric‐inspired regimen |
| title_sort | safety of re challenging adults with acute lymphoblastic leukemia with peg asparaginase induced severe hypertriglyceridemia when treated with a pediatric inspired regimen |
| topic | acute lymphoblastic leukemia acute pancreatitis hypertriglyceridemia PEG‐asparaginase toxicity |
| url | https://doi.org/10.1002/jha2.607 |
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