Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis
Objective Hepatocellular carcinoma (HCC) incidence in the UK trebled between 1997 and 2017. With increasing numbers requiring treatment, understanding the likely impact on healthcare budgets can inform service planning and commissioning. The aim of this analysis was to use existing registry data to...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2023-05-01
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| Series: | BMJ Open Gastroenterology |
| Online Access: | https://bmjopengastro.bmj.com/content/10/1/e000998.full |
| _version_ | 1797316158360125440 |
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| author | Graeme Alexander Deborah Fitzsimmons Mari Jones Anya Burton Aileen Marshall Lizz Paley Daniela Tataru Katherine Cullen Rhys D. Pockett Timothy J.S. Cross Ian A. Rowe |
| author_facet | Graeme Alexander Deborah Fitzsimmons Mari Jones Anya Burton Aileen Marshall Lizz Paley Daniela Tataru Katherine Cullen Rhys D. Pockett Timothy J.S. Cross Ian A. Rowe |
| author_sort | Graeme Alexander |
| collection | DOAJ |
| description | Objective Hepatocellular carcinoma (HCC) incidence in the UK trebled between 1997 and 2017. With increasing numbers requiring treatment, understanding the likely impact on healthcare budgets can inform service planning and commissioning. The aim of this analysis was to use existing registry data to describe the direct healthcare costs of current treatments for HCC and estimate the impact on National Health Service (NHS) budgets.Design A retrospective data analysis based on the National Cancer Registration and Analysis Service cancer registry informed a decision-analytic model for England comparing patients by cirrhosis compensation status and those on palliative or curative treatment pathways. Potential cost drivers were investigated by undertaking a series of one-way sensitivity analyses.Results Between 1 January 2010 and 31 December 2016, 15 684 patients were diagnosed with HCC. The median cost per patient over 2 years was £9065 (IQR: £1965 to £20 491), 66% did not receive active therapy. The cost of HCC treatment for England over 5 years was estimated to be £245 million.Conclusion The National Cancer Registration Dataset and linked data sets have enabled a comprehensive analysis of the resource use and costs of secondary and tertiary healthcare for HCC, providing an overview of the economic impact to the NHS England of treating HCC. |
| first_indexed | 2024-03-08T03:15:11Z |
| format | Article |
| id | doaj.art-e511ebcab3314f1eaf84adf11d32d518 |
| institution | Directory Open Access Journal |
| issn | 2054-4774 |
| language | English |
| last_indexed | 2024-03-08T03:15:11Z |
| publishDate | 2023-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open Gastroenterology |
| spelling | doaj.art-e511ebcab3314f1eaf84adf11d32d5182024-02-12T16:50:08ZengBMJ Publishing GroupBMJ Open Gastroenterology2054-47742023-05-0110110.1136/bmjgast-2022-000998Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysisGraeme Alexander0Deborah Fitzsimmons1Mari Jones2Anya Burton3Aileen Marshall4Lizz Paley5Daniela Tataru6Katherine Cullen7Rhys D. Pockett8Timothy J.S. Cross9Ian A. Rowe10Institute for Liver and Digestive Health, Division of Medicine, University College London, London, UKFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, UKFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, UKBristol Medical School, Translational Health Sciences, University of Bristol, Bristol, UKSheila Sherlock Liver Centre, Royal Free London NHS Foundation Trust, London, UKNational Cancer Registration and Analysis Service, National Disease Registration Service, NHS Digital, UKNational Cancer Registration and Analysis Service, National Disease Registration Service, NHS Digital, UKFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, UKFaculty of Medicine, Health and Life Sciences, Swansea University, Swansea, UKConsultant in Liver Medicine, Department of Gastroenterology & Hepatology, The Royal Liverpool University Hospital, Liverpool, UKLeeds Institute for Medical Research, School of Medicine, University of Leeds, Leeds, UKObjective Hepatocellular carcinoma (HCC) incidence in the UK trebled between 1997 and 2017. With increasing numbers requiring treatment, understanding the likely impact on healthcare budgets can inform service planning and commissioning. The aim of this analysis was to use existing registry data to describe the direct healthcare costs of current treatments for HCC and estimate the impact on National Health Service (NHS) budgets.Design A retrospective data analysis based on the National Cancer Registration and Analysis Service cancer registry informed a decision-analytic model for England comparing patients by cirrhosis compensation status and those on palliative or curative treatment pathways. Potential cost drivers were investigated by undertaking a series of one-way sensitivity analyses.Results Between 1 January 2010 and 31 December 2016, 15 684 patients were diagnosed with HCC. The median cost per patient over 2 years was £9065 (IQR: £1965 to £20 491), 66% did not receive active therapy. The cost of HCC treatment for England over 5 years was estimated to be £245 million.Conclusion The National Cancer Registration Dataset and linked data sets have enabled a comprehensive analysis of the resource use and costs of secondary and tertiary healthcare for HCC, providing an overview of the economic impact to the NHS England of treating HCC.https://bmjopengastro.bmj.com/content/10/1/e000998.full |
| spellingShingle | Graeme Alexander Deborah Fitzsimmons Mari Jones Anya Burton Aileen Marshall Lizz Paley Daniela Tataru Katherine Cullen Rhys D. Pockett Timothy J.S. Cross Ian A. Rowe Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis BMJ Open Gastroenterology |
| title | Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis |
| title_full | Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis |
| title_fullStr | Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis |
| title_full_unstemmed | Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis |
| title_short | Cost of hepatocellular carcinoma to the national health service in England: a registry-based analysis |
| title_sort | cost of hepatocellular carcinoma to the national health service in england a registry based analysis |
| url | https://bmjopengastro.bmj.com/content/10/1/e000998.full |
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