Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity
Sacha Inchi (Plukenetia huayllabambana), an oleoleguminosae with a high content ω-3, could help normalize alterations of obesity. We evaluated the effect of emulsion of Sacha Inchi (SI) oil on the lipid profile, oxidative stress and inflammation in serum and liver tissue of obesity-induced rats. Fiv...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2020-01-01
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| Series: | Journal of Functional Foods |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1756464619305559 |
| _version_ | 1819291976054341632 |
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| author | Johnny P. Ambulay Percy A. Rojas Olga S. Timoteo Teresa V. Barreto Ana Colarossi |
| author_facet | Johnny P. Ambulay Percy A. Rojas Olga S. Timoteo Teresa V. Barreto Ana Colarossi |
| author_sort | Johnny P. Ambulay |
| collection | DOAJ |
| description | Sacha Inchi (Plukenetia huayllabambana), an oleoleguminosae with a high content ω-3, could help normalize alterations of obesity. We evaluated the effect of emulsion of Sacha Inchi (SI) oil on the lipid profile, oxidative stress and inflammation in serum and liver tissue of obesity-induced rats. Five groups induced to obesity by high-fat diet were analyzed. One group without treatment, two groups with the emulsion of SI oil (OSI1:0.25 ω-3/day, OSI2:0.5 ω-3/day), one group with atorvastatin and one group with atorvastatin plus the emulsion of SI oil. The treated groups lowered the values of total cholesterol, triglycerides, and LDLc, and increased HDLc. The lipid and protein oxidation marker, IL-6 and leptin decreased in serum, as well as TNF-α hepatic. In contrast, serum adiponectin, antioxidant capacity, and liver catalase activity increased in the OSI2 group. Therefore, the emulsion of SI oil normalizes the lipid profile and decreases oxidative stress and inflammation in an obesity model. |
| first_indexed | 2024-12-24T03:47:11Z |
| format | Article |
| id | doaj.art-e512a17b8dce4442b3f08df3a6571429 |
| institution | Directory Open Access Journal |
| issn | 1756-4646 |
| language | English |
| last_indexed | 2024-12-24T03:47:11Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Functional Foods |
| spelling | doaj.art-e512a17b8dce4442b3f08df3a65714292022-12-21T17:16:41ZengElsevierJournal of Functional Foods1756-46462020-01-0164103631Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesityJohnny P. Ambulay0Percy A. Rojas1Olga S. Timoteo2Teresa V. Barreto3Ana Colarossi4Micronutrients Laboratory, Laboratories for Research and Development, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 31, Peru; Correspondence author.Unit of Molecular Biotechnology, Laboratories for Research and Development, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 31, PeruBioincuba, Calle José Antonio N°310 Urb. Camacho, La Molina, Lima 12, PeruUnit of Molecular Biotechnology, Laboratories for Research and Development, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 31, PeruMicronutrients Laboratory, Laboratories for Research and Development, Universidad Peruana Cayetano Heredia, Av. Honorio Delgado 430, San Martin de Porres, Lima 31, PeruSacha Inchi (Plukenetia huayllabambana), an oleoleguminosae with a high content ω-3, could help normalize alterations of obesity. We evaluated the effect of emulsion of Sacha Inchi (SI) oil on the lipid profile, oxidative stress and inflammation in serum and liver tissue of obesity-induced rats. Five groups induced to obesity by high-fat diet were analyzed. One group without treatment, two groups with the emulsion of SI oil (OSI1:0.25 ω-3/day, OSI2:0.5 ω-3/day), one group with atorvastatin and one group with atorvastatin plus the emulsion of SI oil. The treated groups lowered the values of total cholesterol, triglycerides, and LDLc, and increased HDLc. The lipid and protein oxidation marker, IL-6 and leptin decreased in serum, as well as TNF-α hepatic. In contrast, serum adiponectin, antioxidant capacity, and liver catalase activity increased in the OSI2 group. Therefore, the emulsion of SI oil normalizes the lipid profile and decreases oxidative stress and inflammation in an obesity model.http://www.sciencedirect.com/science/article/pii/S1756464619305559ObesityLipid profileOxidative stressInflammationSacha Inchi |
| spellingShingle | Johnny P. Ambulay Percy A. Rojas Olga S. Timoteo Teresa V. Barreto Ana Colarossi Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity Journal of Functional Foods Obesity Lipid profile Oxidative stress Inflammation Sacha Inchi |
| title | Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity |
| title_full | Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity |
| title_fullStr | Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity |
| title_full_unstemmed | Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity |
| title_short | Effect of the emulsion of Sacha Inchi (Plukenetia huayabambana) oil on oxidative stress and inflammation in rats induced to obesity |
| title_sort | effect of the emulsion of sacha inchi plukenetia huayabambana oil on oxidative stress and inflammation in rats induced to obesity |
| topic | Obesity Lipid profile Oxidative stress Inflammation Sacha Inchi |
| url | http://www.sciencedirect.com/science/article/pii/S1756464619305559 |
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