The Identification by Exome Sequencing of Candidate Genes in <i>BRCA</i>-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer

The Identification by Exome Sequencing of Candidate Genes in <i>BRCA</i>-Negative Tunisian Patients at a High Risk of Hereditary Breast/Ovarian Cancer

(1) Background: Germline variants in <i>BRCA1/BRCA2</i> genes explain about 20% of hereditary breast/ovarian cancer (HBOC) cases. In the present paper, we aim to identify genetic determinants in <i>BRCA</i>-negative families from the South of Tunisia. (2) Methods: Exome Seque...

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Bibliographic Details
Main Authors: Dorra BenAyed-Guerfali, Chamseddine Kifagi, Wala BenKridis-Rejeb, Nihel Ammous-Boukhris, Wajdi Ayedi, Afef Khanfir, Jamel Daoud, Raja Mokdad-Gargouri
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Genes
Subjects:
<i>BRCA1/BRCA2</i> genes
hereditary breast/ovarian cancer
exome sequencing
germline variants
candidate genes
pathogenic variants
Online Access:https://www.mdpi.com/2073-4425/13/8/1296

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https://www.mdpi.com/2073-4425/13/8/1296

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