Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains
Deubiquitinases (DUBs) targeting Met1-linked ubiquitin chains have important functions in mammals but are barely studied in plants. Here, the authors identify rice OTUB1 as a Met1-targeting DUB, characterize the structural determinants of this activity, and show that these features are conserved in...
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32364-3 |
| _version_ | 1818499073953497088 |
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| author | Lining Lu Xiaoguo Zhai Xiaolong Li Shuansuo Wang Lijun Zhang Luyang Wang Xi Jin Lujun Liang Zhiheng Deng Zichen Li Yanfeng Wang Xiangdong Fu Honggang Hu Jiawei Wang Ziqing Mei Zhengguo He Feng Wang |
| author_facet | Lining Lu Xiaoguo Zhai Xiaolong Li Shuansuo Wang Lijun Zhang Luyang Wang Xi Jin Lujun Liang Zhiheng Deng Zichen Li Yanfeng Wang Xiangdong Fu Honggang Hu Jiawei Wang Ziqing Mei Zhengguo He Feng Wang |
| author_sort | Lining Lu |
| collection | DOAJ |
| description | Deubiquitinases (DUBs) targeting Met1-linked ubiquitin chains have important functions in mammals but are barely studied in plants. Here, the authors identify rice OTUB1 as a Met1-targeting DUB, characterize the structural determinants of this activity, and show that these features are conserved in green plants. |
| first_indexed | 2024-12-10T20:24:18Z |
| format | Article |
| id | doaj.art-e514a51f661245e3ac65fb1d14ad214b |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-10T20:24:18Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-e514a51f661245e3ac65fb1d14ad214b2022-12-22T01:34:55ZengNature PortfolioNature Communications2041-17232022-08-0113111410.1038/s41467-022-32364-3Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chainsLining Lu0Xiaoguo Zhai1Xiaolong Li2Shuansuo Wang3Lijun Zhang4Luyang Wang5Xi Jin6Lujun Liang7Zhiheng Deng8Zichen Li9Yanfeng Wang10Xiangdong Fu11Honggang Hu12Jiawei Wang13Ziqing Mei14Zhengguo He15Feng Wang16State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityKey Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Science, Beijing Institute of TechnologyShanxi Key Laboratory of Minor Crops Germplasm Innovation and Molecular Breeding, Shanxi Agricultural UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityTsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua UniversityTsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua UniversityTsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua UniversityKey Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Science, Beijing Institute of TechnologyThe State Key Laboratory of Plant Cell and Chromosome Engineering, Institute of Genetics and Developmental Biology, Chinese Academy of SciencesTsinghua-Peking Center for Life Sciences, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Center for Synthetic and Systems Biology, State Key Laboratory of Chemical Oncogenomics (Shenzhen), Department of Chemistry, Tsinghua UniversityState Key Laboratory of Membrane Biology, Tsinghua UniversitySchool of Chemistry and Biological Engineering, University of Science and Technology BeijingState Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, College of Life Science and Technology, Guangxi UniversityKey Laboratory of Molecular Medicine and Biotherapy in the Ministry of Industry and Information Technology, Department of Biology, School of Life Science, Beijing Institute of TechnologyDeubiquitinases (DUBs) targeting Met1-linked ubiquitin chains have important functions in mammals but are barely studied in plants. Here, the authors identify rice OTUB1 as a Met1-targeting DUB, characterize the structural determinants of this activity, and show that these features are conserved in green plants.https://doi.org/10.1038/s41467-022-32364-3 |
| spellingShingle | Lining Lu Xiaoguo Zhai Xiaolong Li Shuansuo Wang Lijun Zhang Luyang Wang Xi Jin Lujun Liang Zhiheng Deng Zichen Li Yanfeng Wang Xiangdong Fu Honggang Hu Jiawei Wang Ziqing Mei Zhengguo He Feng Wang Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nature Communications |
| title | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains |
| title_full | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains |
| title_fullStr | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains |
| title_full_unstemmed | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains |
| title_short | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains |
| title_sort | met1 specific motifs conserved in otub subfamily of green plants enable rice otub1 to hydrolyse met1 ubiquitin chains |
| url | https://doi.org/10.1038/s41467-022-32364-3 |
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