Update in Hyperferritinemic Syndromes: Recognition and Management - A Scoping Review
Elevated serum ferritin is a marker of macrophage activation and is associated with increased mortality. The hyperferritinemic syndromes which include hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), catastrophic antiphospholipid syndrome (CAPS), septic shock, adult...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Department of Medicine, Warren Alpert Medical School at Brown University
2022-08-01
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| Series: | Brown Journal of Hospital Medicine |
| Online Access: | https://doi.org/10.56305/001c.37667 |
| Summary: | Elevated serum ferritin is a marker of macrophage activation and is associated with increased mortality. The hyperferritinemic syndromes which include hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS), catastrophic antiphospholipid syndrome (CAPS), septic shock, adult-onset Still’s Disease (AOSD), and multi-inflammatory syndrome related to COVID-19 (MIS-C/A) are characterized by intense inflammation and its sequalae. Prompt recognition and management of these heterogenous disorders is required to improve patient outcomes. We perform a scoping review of the existing literature on the key features of these rare syndromes. |
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| ISSN: | 2831-5553 |