Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD)
Bone morphogenetic proteins (BMPs) have diverse andimportant roles in the proliferation and differentiation of adultstem cells in our tissues. Especially, BMPs are well known tobe the main inducers of bone formation, by facilitating bothproliferation and differentiation of bone stem cells.Interestin...
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| Format: | Article |
| Language: | English |
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Korean Society for Biochemistry and Molecular Biology
2013-09-01
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| Series: | BMB Reports |
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| Online Access: | http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTczM18lMjg0NjUtNDcwJTI5Qk1CXzEyLTIzOC0xLnBkZg== |
| _version_ | 1818315697309089792 |
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| author | Byung-Hak Yoon Yun-Hui Jeon Byunghee Hwang Hyuknam Kwon Senyon Choe Zungyoon Yang |
| author_facet | Byung-Hak Yoon Yun-Hui Jeon Byunghee Hwang Hyuknam Kwon Senyon Choe Zungyoon Yang |
| author_sort | Byung-Hak Yoon |
| collection | DOAJ |
| description | Bone morphogenetic proteins (BMPs) have diverse andimportant roles in the proliferation and differentiation of adultstem cells in our tissues. Especially, BMPs are well known tobe the main inducers of bone formation, by facilitating bothproliferation and differentiation of bone stem cells.Interestingly, in skin stem cells, BMPs repress their proliferationbut are indispensable for the proper differentiation intoseveral lineages of skin cells. Here, we tested whether BMPantagonists have an effect on the prevention of wrinkleformation. For this study we used an in vivo wrinkle-inducedmouse model. As a positive control, retinoic acid, one of thetop anti-wrinkle effectors, showed a 44% improvementcompared to the non-treated control. Surprisingly, bonemorphogenetic protein receptor 1a extracellular domain(BMPR1a-ECD) exhibited an anti-wrinkle effect which was6-fold greater than that of retinoic acid. Our results indicatethat BMP antagonists will be good targets for skin or hairdiseases. [BMB Reports 2013; 46(9): 465-470] |
| first_indexed | 2024-12-13T09:09:39Z |
| format | Article |
| id | doaj.art-e515dd2f12c14d9eb796e4a995608ce5 |
| institution | Directory Open Access Journal |
| issn | 1976-6696 1976-670X |
| language | English |
| last_indexed | 2024-12-13T09:09:39Z |
| publishDate | 2013-09-01 |
| publisher | Korean Society for Biochemistry and Molecular Biology |
| record_format | Article |
| series | BMB Reports |
| spelling | doaj.art-e515dd2f12c14d9eb796e4a995608ce52022-12-21T23:52:58ZengKorean Society for Biochemistry and Molecular BiologyBMB Reports1976-66961976-670X2013-09-01469465470http://dx.doi.org/10.5483/BMBRep.2013.46.9.238Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD)Byung-Hak YoonYun-Hui JeonByunghee HwangHyuknam KwonSenyon ChoeZungyoon YangBone morphogenetic proteins (BMPs) have diverse andimportant roles in the proliferation and differentiation of adultstem cells in our tissues. Especially, BMPs are well known tobe the main inducers of bone formation, by facilitating bothproliferation and differentiation of bone stem cells.Interestingly, in skin stem cells, BMPs repress their proliferationbut are indispensable for the proper differentiation intoseveral lineages of skin cells. Here, we tested whether BMPantagonists have an effect on the prevention of wrinkleformation. For this study we used an in vivo wrinkle-inducedmouse model. As a positive control, retinoic acid, one of thetop anti-wrinkle effectors, showed a 44% improvementcompared to the non-treated control. Surprisingly, bonemorphogenetic protein receptor 1a extracellular domain(BMPR1a-ECD) exhibited an anti-wrinkle effect which was6-fold greater than that of retinoic acid. Our results indicatethat BMP antagonists will be good targets for skin or hairdiseases. [BMB Reports 2013; 46(9): 465-470]http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTczM18lMjg0NjUtNDcwJTI5Qk1CXzEyLTIzOC0xLnBkZg==Anti-wrinkleBone morphogenetic proteinsBone morphogenetic protein receptor 1a extracellular domainCollagenSkin stem cells |
| spellingShingle | Byung-Hak Yoon Yun-Hui Jeon Byunghee Hwang Hyuknam Kwon Senyon Choe Zungyoon Yang Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) BMB Reports Anti-wrinkle Bone morphogenetic proteins Bone morphogenetic protein receptor 1a extracellular domain Collagen Skin stem cells |
| title | Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) |
| title_full | Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) |
| title_fullStr | Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) |
| title_full_unstemmed | Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) |
| title_short | Anti-wrinkle effect of bone morphogenetic protein receptor 1a-extracellular domain (BMPR1a-ECD) |
| title_sort | anti wrinkle effect of bone morphogenetic protein receptor 1a extracellular domain bmpr1a ecd |
| topic | Anti-wrinkle Bone morphogenetic proteins Bone morphogenetic protein receptor 1a extracellular domain Collagen Skin stem cells |
| url | http://bmbreports.org/jbmb/pdf.php?data=MTMxMDA3MTZAcGRmX3JhaW50cmFjZV9sZWV5c0AlNUI0Ni05JTVEMTMwOTI2MTczM18lMjg0NjUtNDcwJTI5Qk1CXzEyLTIzOC0xLnBkZg== |
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