Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults
Abstract Background The atherogenic index of plasma (AIP) can reflect the burden of atherosclerosis. Hyperglycemia is one of the leading causes of atherosclerosis. However, the relationship between AIP and prediabetes is rarely studied. Therefore, we aimed to explore the relationship between AIP and...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-023-01934-0 |
| _version_ | 1797454052365172736 |
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| author | Xiaodan Zheng Xin Zhang Yong Han Haofei Hu Changchun Cao |
| author_facet | Xiaodan Zheng Xin Zhang Yong Han Haofei Hu Changchun Cao |
| author_sort | Xiaodan Zheng |
| collection | DOAJ |
| description | Abstract Background The atherogenic index of plasma (AIP) can reflect the burden of atherosclerosis. Hyperglycemia is one of the leading causes of atherosclerosis. However, the relationship between AIP and prediabetes is rarely studied. Therefore, we aimed to explore the relationship between AIP and prediabetes. Methods This retrospective cohort study recruited 100,069 Chinese adults at the Rich Healthcare Group from 2010 to 2016. AIP was calculated according to Log10 (triglyceride/high-density lipoprotein cholesterol) formula. Cox regression method, sensitivity analyses and subgroup analyses were used to examine the relationship between AIP and prediabetes. Cox proportional hazards regression with cubic spline functions and smooth curve fitting was performed to explore the non-linearity between AIP and prediabetes. The two-piece Cox proportional hazards regression model was used to determine the inflection point of AIP on the risk of prediabetes. Results After adjusting for confounding covariates, AIP was positively associated with prediabetes (HR: 1.41, 95%CI: 1.31–1.52, P < 0.0001). The two-piecewise Cox proportional hazards regression model discovered that the AIP’s inflection point was 0.03 (P for log-likelihood ratio test < 0.001). AIP was positively associated with the risk of prediabetes when AIP ≤ 0.03 (HR: 1.90, 95%CI: 1.66–2.16, P < 0.0001). In contrast, When AIP > 0.03, their association was not significant (HR: 1.04, 95%CI: 0.91–1.19, P = 0.5528). Conclusion This study shows that AIP was positively and non-linearly associated with the risk of prediabetes after adjusting for other confounding factors. When AIP ≤ 0.03, AIP was positively associated with the risk of prediabetes. |
| first_indexed | 2024-03-09T15:31:41Z |
| format | Article |
| id | doaj.art-e516be20a269455d80c32d58c154749a |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-09T15:31:41Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-e516be20a269455d80c32d58c154749a2023-11-26T12:15:58ZengBMCCardiovascular Diabetology1475-28402023-08-0122111110.1186/s12933-023-01934-0Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adultsXiaodan Zheng0Xin Zhang1Yong Han2Haofei Hu3Changchun Cao4Department of Neurology, Shenzhen Samii Medical Center (The Fourth People’s Hospital of Shenzhen)Department of Rehabilitation, Shenzhen Dapeng New District Nan’ao People’s HospitalDepartment of Emergency, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen UniversityDepartment of Nephrology, Shenzhen Second People’s Hospital, The First Affiliated Hospital of Shenzhen UniversityDepartment of Rehabilitation, Shenzhen Dapeng New District Nan’ao People’s HospitalAbstract Background The atherogenic index of plasma (AIP) can reflect the burden of atherosclerosis. Hyperglycemia is one of the leading causes of atherosclerosis. However, the relationship between AIP and prediabetes is rarely studied. Therefore, we aimed to explore the relationship between AIP and prediabetes. Methods This retrospective cohort study recruited 100,069 Chinese adults at the Rich Healthcare Group from 2010 to 2016. AIP was calculated according to Log10 (triglyceride/high-density lipoprotein cholesterol) formula. Cox regression method, sensitivity analyses and subgroup analyses were used to examine the relationship between AIP and prediabetes. Cox proportional hazards regression with cubic spline functions and smooth curve fitting was performed to explore the non-linearity between AIP and prediabetes. The two-piece Cox proportional hazards regression model was used to determine the inflection point of AIP on the risk of prediabetes. Results After adjusting for confounding covariates, AIP was positively associated with prediabetes (HR: 1.41, 95%CI: 1.31–1.52, P < 0.0001). The two-piecewise Cox proportional hazards regression model discovered that the AIP’s inflection point was 0.03 (P for log-likelihood ratio test < 0.001). AIP was positively associated with the risk of prediabetes when AIP ≤ 0.03 (HR: 1.90, 95%CI: 1.66–2.16, P < 0.0001). In contrast, When AIP > 0.03, their association was not significant (HR: 1.04, 95%CI: 0.91–1.19, P = 0.5528). Conclusion This study shows that AIP was positively and non-linearly associated with the risk of prediabetes after adjusting for other confounding factors. When AIP ≤ 0.03, AIP was positively associated with the risk of prediabetes.https://doi.org/10.1186/s12933-023-01934-0Atherogenic index of plasmaPrediabetesNon-linearity |
| spellingShingle | Xiaodan Zheng Xin Zhang Yong Han Haofei Hu Changchun Cao Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults Cardiovascular Diabetology Atherogenic index of plasma Prediabetes Non-linearity |
| title | Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults |
| title_full | Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults |
| title_fullStr | Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults |
| title_full_unstemmed | Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults |
| title_short | Nonlinear relationship between atherogenic index of plasma and the risk of prediabetes: a retrospective study based on Chinese adults |
| title_sort | nonlinear relationship between atherogenic index of plasma and the risk of prediabetes a retrospective study based on chinese adults |
| topic | Atherogenic index of plasma Prediabetes Non-linearity |
| url | https://doi.org/10.1186/s12933-023-01934-0 |
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