Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines
Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native β-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether β-CD...
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| Format: | Article |
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MDPI AG
2022-10-01
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| Series: | Pharmaceutics |
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| Online Access: | https://www.mdpi.com/1999-4923/14/11/2283 |
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| author | Hamdy Abdelkader Adel Al Fatease Zeinab Fathalla Mai E. Shoman Heba A. Abou-Taleb Mohammed A. S. Abourehab |
| author_facet | Hamdy Abdelkader Adel Al Fatease Zeinab Fathalla Mai E. Shoman Heba A. Abou-Taleb Mohammed A. S. Abourehab |
| author_sort | Hamdy Abdelkader |
| collection | DOAJ |
| description | Curcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native β-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether β-CD), hydroxypropyl β-cyclodextrin, and hydroxyethyl β-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl β-cyclodextrin, and curcumin: hydroxypropyl β-cyclodextrin were 7.33, 7.28, and 19.05 µg/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl β-cyclodextrin complex on the direct cell lines of MCF-7. |
| first_indexed | 2024-03-09T18:45:31Z |
| format | Article |
| id | doaj.art-e517e85304a44a5dba611b4eca00f16f |
| institution | Directory Open Access Journal |
| issn | 1999-4923 |
| language | English |
| last_indexed | 2024-03-09T18:45:31Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceutics |
| spelling | doaj.art-e517e85304a44a5dba611b4eca00f16f2023-11-24T06:19:40ZengMDPI AGPharmaceutics1999-49232022-10-011411228310.3390/pharmaceutics14112283Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell LinesHamdy Abdelkader0Adel Al Fatease1Zeinab Fathalla2Mai E. Shoman3Heba A. Abou-Taleb4Mohammed A. S. Abourehab5Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Pharmaceutics, College of Pharmacy, King Khalid University, Abha 62529, Saudi ArabiaDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, EgyptDepartment of Medicinal Chemistry, Faculty of Pharmacy, Minia University, Minia 61519, EgyptDepartment of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Merit University (MUE), Sohag 82755, EgyptDepartment of Pharmaceutics, Faculty of Pharmacy, Minia University, Minia 61519, EgyptCurcumin is one of the most researched phytochemicals by pharmacologists and formulation scientists to unleash its potential therapeutic benefits and tackle inherent biopharmaceutic problems. In this study, the native β-cyclodextrin (CD) and three derivatives, namely, Captisol (sulfobutyl ether β-CD), hydroxypropyl β-cyclodextrin, and hydroxyethyl β-cyclodextrin were investigated for inclusion complexes with curcumin using two preparation methods (physical mixing and solvent evaporation). The prepared complexes were studied for docking, solubility, FTIR, DSC, XRD, and dissolution rates. The best-fitting curcumin: cyclodextrins (the latter of the two CDs) were evaluated for cytotoxicity using human breast cell lines (MCF-7). Dose-dependent cytotoxicity was recorded as IC50% for curcumin, curcumin: hydroxyethyl β-cyclodextrin, and curcumin: hydroxypropyl β-cyclodextrin were 7.33, 7.28, and 19.05 µg/mL, respectively. These research findings indicate a protective role for the curcumin: hydroxypropyl β-cyclodextrin complex on the direct cell lines of MCF-7.https://www.mdpi.com/1999-4923/14/11/2283curcumincyclodextrinshydroxyethyl β-cyclodextrinMCF-7solubilitycytotoxicity |
| spellingShingle | Hamdy Abdelkader Adel Al Fatease Zeinab Fathalla Mai E. Shoman Heba A. Abou-Taleb Mohammed A. S. Abourehab Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines Pharmaceutics curcumin cyclodextrins hydroxyethyl β-cyclodextrin MCF-7 solubility cytotoxicity |
| title | Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines |
| title_full | Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines |
| title_fullStr | Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines |
| title_full_unstemmed | Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines |
| title_short | Design, Preparation and Evaluation of Supramolecular Complexes with Curcumin for Enhanced Cytotoxicity in Breast Cancer Cell Lines |
| title_sort | design preparation and evaluation of supramolecular complexes with curcumin for enhanced cytotoxicity in breast cancer cell lines |
| topic | curcumin cyclodextrins hydroxyethyl β-cyclodextrin MCF-7 solubility cytotoxicity |
| url | https://www.mdpi.com/1999-4923/14/11/2283 |
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