Propofol suppresses cell viability, cell cycle progression and motility and induces cell apoptosis of ovarian cancer cells through suppressing MEK/ERK signaling via targeting circVPS13C/miR-145 axis

Propofol suppresses cell viability, cell cycle progression and motility and induces cell apoptosis of ovarian cancer cells through suppressing MEK/ERK signaling via targeting circVPS13C/miR-145 axis

Abstract Background Propofol is a kind of common intravenous anaesthetic agent that plays an anti-tumor role in a variety of cancers, including ovarian cancer. However, the working mechanism of Propofol in ovarian cancer needs further exploration. Methods The viability and metastasis of ovarian canc...

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Bibliographic Details
Main Authors: Huan Lu, Guanlin Zheng, Xiang Gao, Chanjuan Chen, Min Zhou, Longxin Zhang
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Ovarian Research
Subjects:
Ovarian cancer
Propofol
circVPS13C
miR-145
MEK/ERK signaling
Online Access:https://doi.org/10.1186/s13048-021-00775-3

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