Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation
This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were s...
| Κύριοι συγγραφείς: | , , , , , , , , , , , |
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| Μορφή: | Άρθρο |
| Γλώσσα: | English |
| Έκδοση: |
Ferrata Storti Foundation
2008-02-01
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| Σειρά: | Haematologica |
| Διαθέσιμο Online: | https://haematologica.org/article/view/4756 |
| _version_ | 1827217163486756864 |
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| author | Mohamad Mohty Myriam Labopin Reza Tabrizzi Niklas Theorin Axel A Fauser Alessandro Rambaldi Johan Maertens Shimon Slavin Ignazio Majolino Arnon Nagler Didier Blaise Vanderson Rocha |
| author_facet | Mohamad Mohty Myriam Labopin Reza Tabrizzi Niklas Theorin Axel A Fauser Alessandro Rambaldi Johan Maertens Shimon Slavin Ignazio Majolino Arnon Nagler Didier Blaise Vanderson Rocha |
| author_sort | Mohamad Mohty |
| collection | DOAJ |
| description | This retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%; 42±10%; and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation. |
| first_indexed | 2025-03-21T15:14:39Z |
| format | Article |
| id | doaj.art-e51ba6c1e6b64cbb90fe258ae2ce860f |
| institution | Directory Open Access Journal |
| issn | 0390-6078 1592-8721 |
| language | English |
| last_indexed | 2025-03-21T15:14:39Z |
| publishDate | 2008-02-01 |
| publisher | Ferrata Storti Foundation |
| record_format | Article |
| series | Haematologica |
| spelling | doaj.art-e51ba6c1e6b64cbb90fe258ae2ce860f2024-06-19T23:13:21ZengFerrata Storti FoundationHaematologica0390-60781592-87212008-02-0193210.3324/haematol.11960Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow TransplantationMohamad MohtyMyriam LabopinReza TabrizziNiklas TheorinAxel A FauserAlessandro RambaldiJohan MaertensShimon SlavinIgnazio MajolinoArnon NaglerDidier BlaiseVanderson RochaThis retrospective study reported the outcome of 97 adult acute lymphoblastic leukemia patients who received a reduced-intensity conditioning allogeneic stem cell transplantation. With a median follow-up of 2.8 years, two year overall-survival, leukemia-free survival and non-relapse mortality were significantly better in patients transplanted in first complete remission (CR1, 52±9%; 42±10%; and 18±7% respectively) compared with those transplanted in more advanced phase (p=0.003, p=0.002 and p=0.01 respectively). In multivariate analysis, disease status (CR1 vs. advanced; p=0.001) and chronic graft-vs-host disease (p=0.01) were associated with an improved overall-survival, suggesting that reduced-intensity conditioning allogeneic stem cell transplantation is feasible in patients with high risk lymphoblastic leukemia in remission at transplantation.https://haematologica.org/article/view/4756 |
| spellingShingle | Mohamad Mohty Myriam Labopin Reza Tabrizzi Niklas Theorin Axel A Fauser Alessandro Rambaldi Johan Maertens Shimon Slavin Ignazio Majolino Arnon Nagler Didier Blaise Vanderson Rocha Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation Haematologica |
| title | Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation |
| title_full | Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation |
| title_fullStr | Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation |
| title_full_unstemmed | Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation |
| title_short | Reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia: a retrospective study from the European Group for Blood and Marrow Transplantation |
| title_sort | reduced intensity conditioning allogeneic stem cell transplantation for adult patients with acute lymphoblastic leukemia a retrospective study from the european group for blood and marrow transplantation |
| url | https://haematologica.org/article/view/4756 |
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