Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence

Insights on Mycobacterium leprae Efflux Pumps and Their Implications in Drug Resistance and Virulence

Drug resistance in Mycobacterium leprae is assumed to be due to genetic alterations in the drug targets and reduced cell wall permeability. However, as observed in Mycobacterium tuberculosis, drug resistance may also result from the overactivity of efflux systems, which is mostly unexplored. In this...

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Bibliographic Details
Main Authors: Diana Machado, Emmanuel Lecorche, Faiza Mougari, Emmanuelle Cambau, Miguel Viveiros
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Microbiology
Subjects:
antimicrobial resistance
efflux pumps
leprosy
mycobacteria
tuberculosis
virulence
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.03072/full

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