Physiological Perspectives on the Use of Triheptanoin as Anaplerotic Therapy for Long Chain Fatty Acid Oxidation Disorders

Physiological Perspectives on the Use of Triheptanoin as Anaplerotic Therapy for Long Chain Fatty Acid Oxidation Disorders

Inborn errors of mitochondrial fatty acid oxidation (FAO) comprise the most common group of disorders identified through expanded newborn screening mandated in all 50 states in the United States, affecting 1:10,000 newborns. While some of the morbidity in FAO disorders (FAODs) can be reduced if iden...

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Bibliographic Details
Main Authors: Evgenia Sklirou, Ahmad N. Alodaib, Steven F. Dobrowolski, Al-Walid A. Mohsen, Jerry Vockley
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Genetics
Subjects:
metabolomics
very long chain acyl-CoA dehydrogenase
fatty acid oxidation disorders
energy metabolism
tricarboxylic acid cycle
anaplerosis
Online Access:https://www.frontiersin.org/articles/10.3389/fgene.2020.598760/full

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