Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis
Objective To evaluate the imaging changes in patients with cerebral small vessel disease(cSVD) and the risk factors of Alzheimer's disease(AD). Methods Retrieve relevant retrospective case analysis and observational studies that about cSVD and the risk factors of AD from online database (Januar...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Tianjin Huanhu Hospital
2019-07-01
|
| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/1979 |
| _version_ | 1830206840409948160 |
|---|---|
| author | Xin LIN Hai⁃jiao WANG Li⁃na ZHU Shan⁃shan CHU Xue⁃ping WANG Ling LIU |
| author_facet | Xin LIN Hai⁃jiao WANG Li⁃na ZHU Shan⁃shan CHU Xue⁃ping WANG Ling LIU |
| author_sort | Xin LIN |
| collection | DOAJ |
| description | Objective To evaluate the imaging changes in patients with cerebral small vessel disease(cSVD) and the risk factors of Alzheimer's disease(AD). Methods Retrieve relevant retrospective case analysis and observational studies that about cSVD and the risk factors of AD from online database (January 1, 1980-April 1, 2019) as PubMed, EMBASE/SCOPUS and Cochrane Library with key words: Alzheimer's disease, cerebral small vessel disease, white matter lesion, cerebral microbleeds, lacunar infarction. Selection of studies was performed according to pre⁃designed inclusion and exclusion criteria. Quality of studies was evaluated by using Newcastle⁃Ottawa Scale (NOS). All data were pooled by Stata 15.1 software for Meta⁃analysis. Results A total of 1452 articles were enrolled, from which 11 studies with NOS score≥5 were chosen after excluding duplicates and those not meeting the inclusion criteria. A total of 12882 patients were included. Meta⁃analysis showed that white matter lesion (RR=1.152,95%CI: 1.007-1.317; P=0.039) and cerebral microbleeds (RR=1.659, 95%CI: 1.085-2.537; P=0.019)increased the risk of AD;lacunar infarc did not increase the risk of AD(RR=1.298,95%CI:0.785-2.147; P=0.309). Conclusions The risk of Alzheimer's disease is increased in patients with white matter lesion and cerebral microbleeds. The cerebral small vessel disease may be involved in the occurrence of some Alzheimer's disease. When patients have the imaging changes of white matter lesion and cerebral microbleeds, should be paid on primary prevention of Alzheimer's disease. |
| first_indexed | 2024-12-18T04:20:52Z |
| format | Article |
| id | doaj.art-e51e8318014c4088bd2f6f479c233cd3 |
| institution | Directory Open Access Journal |
| issn | 1672-6731 1672-6731 |
| language | English |
| last_indexed | 2024-12-18T04:20:52Z |
| publishDate | 2019-07-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-e51e8318014c4088bd2f6f479c233cd32022-12-21T21:21:15ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67311672-67312019-07-0119747448010.3969/j.issn.1672⁃6731.2019.07.004Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysisXin LIN0Hai⁃jiao WANG1Li⁃na ZHU2Shan⁃shan CHU3Xue⁃ping WANG4Ling LIU 5Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaDepartment of Neurology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, ChinaObjective To evaluate the imaging changes in patients with cerebral small vessel disease(cSVD) and the risk factors of Alzheimer's disease(AD). Methods Retrieve relevant retrospective case analysis and observational studies that about cSVD and the risk factors of AD from online database (January 1, 1980-April 1, 2019) as PubMed, EMBASE/SCOPUS and Cochrane Library with key words: Alzheimer's disease, cerebral small vessel disease, white matter lesion, cerebral microbleeds, lacunar infarction. Selection of studies was performed according to pre⁃designed inclusion and exclusion criteria. Quality of studies was evaluated by using Newcastle⁃Ottawa Scale (NOS). All data were pooled by Stata 15.1 software for Meta⁃analysis. Results A total of 1452 articles were enrolled, from which 11 studies with NOS score≥5 were chosen after excluding duplicates and those not meeting the inclusion criteria. A total of 12882 patients were included. Meta⁃analysis showed that white matter lesion (RR=1.152,95%CI: 1.007-1.317; P=0.039) and cerebral microbleeds (RR=1.659, 95%CI: 1.085-2.537; P=0.019)increased the risk of AD;lacunar infarc did not increase the risk of AD(RR=1.298,95%CI:0.785-2.147; P=0.309). Conclusions The risk of Alzheimer's disease is increased in patients with white matter lesion and cerebral microbleeds. The cerebral small vessel disease may be involved in the occurrence of some Alzheimer's disease. When patients have the imaging changes of white matter lesion and cerebral microbleeds, should be paid on primary prevention of Alzheimer's disease.http://www.cjcnn.org/index.php/cjcnn/article/view/1979Cerebral small vessel diseases; Alzheimer disease; Magnetic resonance imaging; Meta⁃analysis |
| spellingShingle | Xin LIN Hai⁃jiao WANG Li⁃na ZHU Shan⁃shan CHU Xue⁃ping WANG Ling LIU Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis Chinese Journal of Contemporary Neurology and Neurosurgery Cerebral small vessel diseases; Alzheimer disease; Magnetic resonance imaging; Meta⁃analysis |
| title | Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis |
| title_full | Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis |
| title_fullStr | Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis |
| title_full_unstemmed | Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis |
| title_short | Imaging changes in cerebral small vessel disease and risk factors of Alzheimer's disease: Meta⁃analysis |
| title_sort | imaging changes in cerebral small vessel disease and risk factors of alzheimer s disease meta⁃analysis |
| topic | Cerebral small vessel diseases; Alzheimer disease; Magnetic resonance imaging; Meta⁃analysis |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/1979 |
| work_keys_str_mv | AT xinlin imagingchangesincerebralsmallvesseldiseaseandriskfactorsofalzheimersdiseasemetaanalysis AT haijiaowang imagingchangesincerebralsmallvesseldiseaseandriskfactorsofalzheimersdiseasemetaanalysis AT linazhu imagingchangesincerebralsmallvesseldiseaseandriskfactorsofalzheimersdiseasemetaanalysis AT shanshanchu imagingchangesincerebralsmallvesseldiseaseandriskfactorsofalzheimersdiseasemetaanalysis AT xuepingwang imagingchangesincerebralsmallvesseldiseaseandriskfactorsofalzheimersdiseasemetaanalysis AT lingliu imagingchangesincerebralsmallvesseldiseaseandriskfactorsofalzheimersdiseasemetaanalysis |