Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis

Epigallocatechin gallate alleviates high-fat diet-induced hepatic lipotoxicity by targeting mitochondrial ROS-mediated ferroptosis

Background: Non-alcoholic fatty liver disease (NAFLD) is a chronic advanced liver disease that is highly related to metabolic disorders and induced by a high-fat diet (HFD). Recently, epigallocatechin gallate (EGCG) has been regarded as a protective bioactive polyphenol in green tea that has the abi...

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Bibliographic Details
Main Authors: Shi-Bin Ding, Xiao-Lei Chu, Yu-Xuan Jin, Jin-Jin Jiang, Xiao Zhao, Min Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Pharmacology
Subjects:
epigallocatechin gallate
mitochondrial ROS
ferroptosis
high-fat diet
hepatic lipotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1148814/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2023.1148814/full

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