An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications
Lectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner. Lectins have diverse sources and are classified according to their origins, such as plant lectins, animal lectins, and...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Marine Drugs |
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| Online Access: | https://www.mdpi.com/1660-3397/20/7/430 |
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| author | Mirja Kaizer Ahmmed Shuva Bhowmik Stephen G. Giteru Md. Nazmul Hasan Zilani Parise Adadi Shikder Saiful Islam Osman N. Kanwugu Monjurul Haq Fatema Ahmmed Charlene Cheuk Wing Ng Yau Sang Chan Md. Asadujjaman Gabriel Hoi Huen Chan Ryno Naude Alaa El-Din Ahmed Bekhit Tzi Bun Ng Jack Ho Wong |
| author_facet | Mirja Kaizer Ahmmed Shuva Bhowmik Stephen G. Giteru Md. Nazmul Hasan Zilani Parise Adadi Shikder Saiful Islam Osman N. Kanwugu Monjurul Haq Fatema Ahmmed Charlene Cheuk Wing Ng Yau Sang Chan Md. Asadujjaman Gabriel Hoi Huen Chan Ryno Naude Alaa El-Din Ahmed Bekhit Tzi Bun Ng Jack Ho Wong |
| author_sort | Mirja Kaizer Ahmmed |
| collection | DOAJ |
| description | Lectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner. Lectins have diverse sources and are classified according to their origins, such as plant lectins, animal lectins, and fish lectins. Marine organisms including fish, crustaceans, and mollusks produce a myriad of lectins, including rhamnose binding lectins (RBL), fucose-binding lectins (FTL), mannose-binding lectin, galectins, galactose binding lectins, and C-type lectins. The widely used method of extracting lectins from marine samples is a simple two-step process employing a polar salt solution and purification by column chromatography. Lectins exert several immunomodulatory functions, including pathogen recognition, inflammatory reactions, participating in various hemocyte functions (e.g., agglutination), phagocytic reactions, among others. Lectins can also control cell proliferation, protein folding, RNA splicing, and trafficking of molecules. Due to their reported biological and pharmaceutical activities, lectins have attracted the attention of scientists and industries (i.e., food, biomedical, and pharmaceutical industries). Therefore, this review aims to update current information on lectins from marine organisms, their characterization, extraction, and biofunctionalities. |
| first_indexed | 2024-03-09T13:29:41Z |
| format | Article |
| id | doaj.art-e51fbcab46a546c4af812a633c3d365c |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-09T13:29:41Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-e51fbcab46a546c4af812a633c3d365c2023-11-30T21:20:09ZengMDPI AGMarine Drugs1660-33972022-06-0120743010.3390/md20070430An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional ApplicationsMirja Kaizer Ahmmed0Shuva Bhowmik1Stephen G. Giteru2Md. Nazmul Hasan Zilani3Parise Adadi4Shikder Saiful Islam5Osman N. Kanwugu6Monjurul Haq7Fatema Ahmmed8Charlene Cheuk Wing Ng9Yau Sang Chan10Md. Asadujjaman11Gabriel Hoi Huen Chan12Ryno Naude13Alaa El-Din Ahmed Bekhit14Tzi Bun Ng15Jack Ho Wong16Department of Food Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandCentre for Bioengineering and Nanomedicine, Faculty of Dentistry, Division of Health Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Food Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandDepartment of Pharmacy, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Food Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandInstitute for Marine and Antarctic Studies, University of Tasmania, Launceston 7250, AustraliaInstitute of Chemical Engineering, Ural Federal University, Mira Street 28, 620002 Yekaterinburg, RussiaDepartment of Fisheries and Marine Bioscience, Jashore University of Science and Technology, Jashore 7408, BangladeshDepartment of Chemistry, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandMedway Maritime Hospital, Medway NHS Foundation Trust, Kent ME7 5NY, UKDepartment of Obstetrics & Gynaecology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, ChinaDepartment of Aquaculture, Faculty of Fisheries and Ocean Sciences, Khulna Agricultural University, Khulna 9100, BangladeshDivision of Science, Engineering and Health Studies, College of Professional and Continuing Education, The Hong Kong Polytechnic University, Hong Kong, ChinaDepartment of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth 6031, South AfricaDepartment of Food Sciences, University of Otago, P.O. Box 56, Dunedin 9054, New ZealandSchool of Life Sciences, The Chinese University of Hong Kong, Hong Kong, ChinaSchool of Health Sciences, Caritas Institute of Higher Education, Hong Kong, ChinaLectins are a unique group of nonimmune carbohydrate-binding proteins or glycoproteins that exhibit specific and reversible carbohydrate-binding activity in a non-catalytic manner. Lectins have diverse sources and are classified according to their origins, such as plant lectins, animal lectins, and fish lectins. Marine organisms including fish, crustaceans, and mollusks produce a myriad of lectins, including rhamnose binding lectins (RBL), fucose-binding lectins (FTL), mannose-binding lectin, galectins, galactose binding lectins, and C-type lectins. The widely used method of extracting lectins from marine samples is a simple two-step process employing a polar salt solution and purification by column chromatography. Lectins exert several immunomodulatory functions, including pathogen recognition, inflammatory reactions, participating in various hemocyte functions (e.g., agglutination), phagocytic reactions, among others. Lectins can also control cell proliferation, protein folding, RNA splicing, and trafficking of molecules. Due to their reported biological and pharmaceutical activities, lectins have attracted the attention of scientists and industries (i.e., food, biomedical, and pharmaceutical industries). Therefore, this review aims to update current information on lectins from marine organisms, their characterization, extraction, and biofunctionalities.https://www.mdpi.com/1660-3397/20/7/430adhesinshemagglutininsmarine lectinscharacterizationextraction and purificationbio-functional roles |
| spellingShingle | Mirja Kaizer Ahmmed Shuva Bhowmik Stephen G. Giteru Md. Nazmul Hasan Zilani Parise Adadi Shikder Saiful Islam Osman N. Kanwugu Monjurul Haq Fatema Ahmmed Charlene Cheuk Wing Ng Yau Sang Chan Md. Asadujjaman Gabriel Hoi Huen Chan Ryno Naude Alaa El-Din Ahmed Bekhit Tzi Bun Ng Jack Ho Wong An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications Marine Drugs adhesins hemagglutinins marine lectins characterization extraction and purification bio-functional roles |
| title | An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications |
| title_full | An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications |
| title_fullStr | An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications |
| title_full_unstemmed | An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications |
| title_short | An Update of Lectins from Marine Organisms: Characterization, Extraction Methodology, and Potential Biofunctional Applications |
| title_sort | update of lectins from marine organisms characterization extraction methodology and potential biofunctional applications |
| topic | adhesins hemagglutinins marine lectins characterization extraction and purification bio-functional roles |
| url | https://www.mdpi.com/1660-3397/20/7/430 |
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