Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis
Ferroptosis is a cell death pathway mediated by iron-dependent accumulation of lipid peroxide. However, the specific downstream molecular events of iron-dependent lipid peroxidation are yet to be elucidated. In this study, based on various spectral analyses, we have found evidence that singlet oxyge...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co. Ltd.
2022-01-01
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| Series: | Fundamental Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667325821001394 |
| _version_ | 1828086099629572096 |
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| author | Xiaofei Zhang Lie Wu Wenyao Zhen Shanshan Li Xiue Jiang |
| author_facet | Xiaofei Zhang Lie Wu Wenyao Zhen Shanshan Li Xiue Jiang |
| author_sort | Xiaofei Zhang |
| collection | DOAJ |
| description | Ferroptosis is a cell death pathway mediated by iron-dependent accumulation of lipid peroxide. However, the specific downstream molecular events of iron-dependent lipid peroxidation are yet to be elucidated. In this study, based on various spectral analyses, we have found evidence that singlet oxygen is produced through the Russell mechanism during the self-reaction of lipid peroxyl radicals generated via iron-dependent lipid peroxidation regardless of the presence of cholesterol. Significantly reduced generation of singlet oxygen was observed in the absence of iron. The generated singlet oxygen accelerated the oxidative damage of lipid membranes by propagating lipid peroxidation and facilitated ferroptotic cancer cell death initiated by erastin. In this work, singlet oxygen has been revealed to be a new reactive species that participates in ferroptosis, thus improving the understanding on iron-dependent lipid peroxidation and the mechanism of ferroptosis. |
| first_indexed | 2024-04-11T04:49:21Z |
| format | Article |
| id | doaj.art-e5209111a1d04c0f8e53171f79d86a7c |
| institution | Directory Open Access Journal |
| issn | 2667-3258 |
| language | English |
| last_indexed | 2024-04-11T04:49:21Z |
| publishDate | 2022-01-01 |
| publisher | KeAi Communications Co. Ltd. |
| record_format | Article |
| series | Fundamental Research |
| spelling | doaj.art-e5209111a1d04c0f8e53171f79d86a7c2022-12-27T04:42:11ZengKeAi Communications Co. Ltd.Fundamental Research2667-32582022-01-01216673Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in FerroptosisXiaofei Zhang0Lie Wu1Wenyao Zhen2Shanshan Li3Xiue Jiang4State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China; Graduate School of University of Science and Technology of China, Anhui 230026, China; Changchun University, Changchun, Jilin 130022, ChinaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China; Corresponding authors.State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China; Graduate School of University of Science and Technology of China, Anhui 230026, ChinaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China; Graduate School of University of Science and Technology of China, Anhui 230026, ChinaState Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Science, Changchun, Jilin 130022, China; Graduate School of University of Science and Technology of China, Anhui 230026, China; Corresponding authors.Ferroptosis is a cell death pathway mediated by iron-dependent accumulation of lipid peroxide. However, the specific downstream molecular events of iron-dependent lipid peroxidation are yet to be elucidated. In this study, based on various spectral analyses, we have found evidence that singlet oxygen is produced through the Russell mechanism during the self-reaction of lipid peroxyl radicals generated via iron-dependent lipid peroxidation regardless of the presence of cholesterol. Significantly reduced generation of singlet oxygen was observed in the absence of iron. The generated singlet oxygen accelerated the oxidative damage of lipid membranes by propagating lipid peroxidation and facilitated ferroptotic cancer cell death initiated by erastin. In this work, singlet oxygen has been revealed to be a new reactive species that participates in ferroptosis, thus improving the understanding on iron-dependent lipid peroxidation and the mechanism of ferroptosis.http://www.sciencedirect.com/science/article/pii/S2667325821001394FerroptosisLipid peroxidationSinglet oxygenRussell mechanism |
| spellingShingle | Xiaofei Zhang Lie Wu Wenyao Zhen Shanshan Li Xiue Jiang Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis Fundamental Research Ferroptosis Lipid peroxidation Singlet oxygen Russell mechanism |
| title | Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis |
| title_full | Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis |
| title_fullStr | Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis |
| title_full_unstemmed | Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis |
| title_short | Generation of singlet oxygen via iron-dependent lipid peroxidation and its role in Ferroptosis |
| title_sort | generation of singlet oxygen via iron dependent lipid peroxidation and its role in ferroptosis |
| topic | Ferroptosis Lipid peroxidation Singlet oxygen Russell mechanism |
| url | http://www.sciencedirect.com/science/article/pii/S2667325821001394 |
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