Application of three-dimensional (3D) bioprinting in anti-cancer therapy
Three-dimensional (3D) bioprinting is a novel technology that enables the creation of 3D structures with bioinks, the biomaterials containing living cells. 3D bioprinted structures can mimic human tissue at different levels of complexity from cells to organs. Currently, 3D bioprinting is a promising...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-10-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844023076831 |
| _version_ | 1797646547914063872 |
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| author | Bing-Xuan Wu Zheng Wu Yan-Yu Hou Ze-Xuan Fang Yu Deng Hua-Tao Wu Jing Liu |
| author_facet | Bing-Xuan Wu Zheng Wu Yan-Yu Hou Ze-Xuan Fang Yu Deng Hua-Tao Wu Jing Liu |
| author_sort | Bing-Xuan Wu |
| collection | DOAJ |
| description | Three-dimensional (3D) bioprinting is a novel technology that enables the creation of 3D structures with bioinks, the biomaterials containing living cells. 3D bioprinted structures can mimic human tissue at different levels of complexity from cells to organs. Currently, 3D bioprinting is a promising method in regenerative medicine and tissue engineering applications, as well as in anti-cancer therapy research. Cancer, a type of complex and multifaceted disease, presents significant challenges regarding diagnosis, treatment, and drug development. 3D bioprinted models of cancer have been used to investigate the molecular mechanisms of oncogenesis, the development of cancers, and the responses to treatment. Conventional 2D cancer models have limitations in predicting human clinical outcomes and drug responses, while 3D bioprinting offers an innovative technique for creating 3D tissue structures that closely mimic the natural characteristics of cancers in terms of morphology, composition, structure, and function. By precise manipulation of the spatial arrangement of different cell types, extracellular matrix components, and vascular networks, 3D bioprinting facilitates the development of cancer models that are more accurate and representative, emulating intricate interactions between cancer cells and their surrounding microenvironment. Moreover, the technology of 3D bioprinting enables the creation of personalized cancer models using patient-derived cells and biomarkers, thereby advancing the fields of precision medicine and immunotherapy. The integration of 3D cell models with 3D bioprinting technology holds the potential to revolutionize cancer research, offering extensive flexibility, precision, and adaptability in crafting customized 3D structures with desired attributes and functionalities. In conclusion, 3D bioprinting exhibits significant potential in cancer research, providing opportunities for identifying therapeutic targets, reducing reliance on animal experiments, and potentially lowering the overall cost of cancer treatment. Further investigation and development are necessary to address challenges such as cell viability, printing resolution, material characteristics, and cost-effectiveness. With ongoing progress, 3D bioprinting can significantly impact the field of cancer research and improve patient outcomes. |
| first_indexed | 2024-03-11T15:04:18Z |
| format | Article |
| id | doaj.art-e523a11e91224dcbbc3ac126874687c7 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-03-11T15:04:18Z |
| publishDate | 2023-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-e523a11e91224dcbbc3ac126874687c72023-10-30T06:06:15ZengElsevierHeliyon2405-84402023-10-01910e20475Application of three-dimensional (3D) bioprinting in anti-cancer therapyBing-Xuan Wu0Zheng Wu1Yan-Yu Hou2Ze-Xuan Fang3Yu Deng4Hua-Tao Wu5Jing Liu6Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaThe Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou 515041, ChinaThe Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou 515041, ChinaThe Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou 515041, ChinaDepartment of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, ChinaDepartment of General Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China; Corresponding author. Department of General Surgery, the First Affiliated Hospital of Shantou University Medical College, No. 57 Changping Road, Shantou 515041, Guangdong Province, China.The Breast Center, Cancer Hospital of Shantou University Medical College, Shantou 515041, China; Department of Physiology/Changjiang Scholar's Laboratory, Shantou University Medical College, Shantou 515041, China; Corresponding author. Guangdong Provincial Key Laboratory for Diagnosis and Treatment of Breast Cancer, Cancer Hospital of Shantou University Medical College, No. 7 Raoping Road, Shantou 515041, Guangdong Province, China.Three-dimensional (3D) bioprinting is a novel technology that enables the creation of 3D structures with bioinks, the biomaterials containing living cells. 3D bioprinted structures can mimic human tissue at different levels of complexity from cells to organs. Currently, 3D bioprinting is a promising method in regenerative medicine and tissue engineering applications, as well as in anti-cancer therapy research. Cancer, a type of complex and multifaceted disease, presents significant challenges regarding diagnosis, treatment, and drug development. 3D bioprinted models of cancer have been used to investigate the molecular mechanisms of oncogenesis, the development of cancers, and the responses to treatment. Conventional 2D cancer models have limitations in predicting human clinical outcomes and drug responses, while 3D bioprinting offers an innovative technique for creating 3D tissue structures that closely mimic the natural characteristics of cancers in terms of morphology, composition, structure, and function. By precise manipulation of the spatial arrangement of different cell types, extracellular matrix components, and vascular networks, 3D bioprinting facilitates the development of cancer models that are more accurate and representative, emulating intricate interactions between cancer cells and their surrounding microenvironment. Moreover, the technology of 3D bioprinting enables the creation of personalized cancer models using patient-derived cells and biomarkers, thereby advancing the fields of precision medicine and immunotherapy. The integration of 3D cell models with 3D bioprinting technology holds the potential to revolutionize cancer research, offering extensive flexibility, precision, and adaptability in crafting customized 3D structures with desired attributes and functionalities. In conclusion, 3D bioprinting exhibits significant potential in cancer research, providing opportunities for identifying therapeutic targets, reducing reliance on animal experiments, and potentially lowering the overall cost of cancer treatment. Further investigation and development are necessary to address challenges such as cell viability, printing resolution, material characteristics, and cost-effectiveness. With ongoing progress, 3D bioprinting can significantly impact the field of cancer research and improve patient outcomes.http://www.sciencedirect.com/science/article/pii/S24058440230768313D bioprintingcancerBioinkTherapyOrganic |
| spellingShingle | Bing-Xuan Wu Zheng Wu Yan-Yu Hou Ze-Xuan Fang Yu Deng Hua-Tao Wu Jing Liu Application of three-dimensional (3D) bioprinting in anti-cancer therapy Heliyon 3D bioprinting cancer Bioink Therapy Organic |
| title | Application of three-dimensional (3D) bioprinting in anti-cancer therapy |
| title_full | Application of three-dimensional (3D) bioprinting in anti-cancer therapy |
| title_fullStr | Application of three-dimensional (3D) bioprinting in anti-cancer therapy |
| title_full_unstemmed | Application of three-dimensional (3D) bioprinting in anti-cancer therapy |
| title_short | Application of three-dimensional (3D) bioprinting in anti-cancer therapy |
| title_sort | application of three dimensional 3d bioprinting in anti cancer therapy |
| topic | 3D bioprinting cancer Bioink Therapy Organic |
| url | http://www.sciencedirect.com/science/article/pii/S2405844023076831 |
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