Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques
Abstract Background Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. Since ASSRs are disturbed in human psychiatric disorders, recording ASS...
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| Format: | Article |
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BMC
2022-09-01
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| Series: | BMC Neuroscience |
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| Online Access: | https://doi.org/10.1186/s12868-022-00741-9 |
| _version_ | 1818024712190558208 |
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| author | Tomoya Nakamura Trong Ha Dinh Makoto Asai Hiroshi Nishimaru Jumpei Matsumoto Tsuyoshi Setogawa Hiroyuki Ichijo Sokichi Honda Hiroshi Yamada Takuma Mihara Hisao Nishijo |
| author_facet | Tomoya Nakamura Trong Ha Dinh Makoto Asai Hiroshi Nishimaru Jumpei Matsumoto Tsuyoshi Setogawa Hiroyuki Ichijo Sokichi Honda Hiroshi Yamada Takuma Mihara Hisao Nishijo |
| author_sort | Tomoya Nakamura |
| collection | DOAJ |
| description | Abstract Background Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. Since ASSRs are disturbed in human psychiatric disorders, recording ASSRs from awake intact macaques would be beneficial to translational research as well as an understanding of human brain function and its pathology. However, ASSR has not been reported in awake macaques. Results Electroencephalograms (EEGs) were recorded from awake intact macaques, while click trains at 20–83.3 Hz were binaurally presented. EEGs were quantified based on event-related spectral perturbation (ERSP) and inter-trial coherence (ITC), and ASSRs were significantly demonstrated in terms of ERSP and ITC in awake intact macaques. A comparison of ASSRs among different click train frequencies indicated that ASSRs were maximal at 83.3 Hz. Furthermore, analyses of laterality indices of ASSRs showed that no laterality dominance of ASSRs was observed. Conclusions The present results demonstrated ASSRs, comparable to those in humans, in awake intact macaques. However, there were some differences in ASSRs between macaques and humans: macaques showed maximal ASSR responses to click frequencies higher than 40 Hz that has been reported to elicit maximal responses in humans, and showed no dominant laterality of ASSRs under the electrode montage in this study compared with humans with right hemisphere dominance. The future ASSR studies using awake intact macaques should be aware of these differences, and possible factors, to which these differences were ascribed, are discussed. |
| first_indexed | 2024-12-10T04:04:34Z |
| format | Article |
| id | doaj.art-e524c69f863b47579967ebd7363f8e43 |
| institution | Directory Open Access Journal |
| issn | 1471-2202 |
| language | English |
| last_indexed | 2024-12-10T04:04:34Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Neuroscience |
| spelling | doaj.art-e524c69f863b47579967ebd7363f8e432022-12-22T02:02:53ZengBMCBMC Neuroscience1471-22022022-09-0123111310.1186/s12868-022-00741-9Characteristics of auditory steady-state responses to different click frequencies in awake intact macaquesTomoya Nakamura0Trong Ha Dinh1Makoto Asai2Hiroshi Nishimaru3Jumpei Matsumoto4Tsuyoshi Setogawa5Hiroyuki Ichijo6Sokichi Honda7Hiroshi Yamada8Takuma Mihara9Hisao Nishijo10System Emotional Science, Faculty of Medicine, University of ToyamaSystem Emotional Science, Faculty of Medicine, University of ToyamaCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc.System Emotional Science, Faculty of Medicine, University of ToyamaSystem Emotional Science, Faculty of Medicine, University of ToyamaSystem Emotional Science, Faculty of Medicine, University of ToyamaDepartment of Anatomy, Faculty of Medicine, University of ToyamaCandidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc.Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc.Candidate Discovery Science Labs, Drug Discovery Research, Astellas Pharma Inc.System Emotional Science, Faculty of Medicine, University of ToyamaAbstract Background Auditory steady-state responses (ASSRs) are periodic evoked responses to constant periodic auditory stimuli, such as click trains, and are suggested to be associated with higher cognitive functions in humans. Since ASSRs are disturbed in human psychiatric disorders, recording ASSRs from awake intact macaques would be beneficial to translational research as well as an understanding of human brain function and its pathology. However, ASSR has not been reported in awake macaques. Results Electroencephalograms (EEGs) were recorded from awake intact macaques, while click trains at 20–83.3 Hz were binaurally presented. EEGs were quantified based on event-related spectral perturbation (ERSP) and inter-trial coherence (ITC), and ASSRs were significantly demonstrated in terms of ERSP and ITC in awake intact macaques. A comparison of ASSRs among different click train frequencies indicated that ASSRs were maximal at 83.3 Hz. Furthermore, analyses of laterality indices of ASSRs showed that no laterality dominance of ASSRs was observed. Conclusions The present results demonstrated ASSRs, comparable to those in humans, in awake intact macaques. However, there were some differences in ASSRs between macaques and humans: macaques showed maximal ASSR responses to click frequencies higher than 40 Hz that has been reported to elicit maximal responses in humans, and showed no dominant laterality of ASSRs under the electrode montage in this study compared with humans with right hemisphere dominance. The future ASSR studies using awake intact macaques should be aware of these differences, and possible factors, to which these differences were ascribed, are discussed.https://doi.org/10.1186/s12868-022-00741-9MonkeyEEGASSRERSPITC |
| spellingShingle | Tomoya Nakamura Trong Ha Dinh Makoto Asai Hiroshi Nishimaru Jumpei Matsumoto Tsuyoshi Setogawa Hiroyuki Ichijo Sokichi Honda Hiroshi Yamada Takuma Mihara Hisao Nishijo Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques BMC Neuroscience Monkey EEG ASSR ERSP ITC |
| title | Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques |
| title_full | Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques |
| title_fullStr | Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques |
| title_full_unstemmed | Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques |
| title_short | Characteristics of auditory steady-state responses to different click frequencies in awake intact macaques |
| title_sort | characteristics of auditory steady state responses to different click frequencies in awake intact macaques |
| topic | Monkey EEG ASSR ERSP ITC |
| url | https://doi.org/10.1186/s12868-022-00741-9 |
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