SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES
Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the mechanism of functioning of the ribokinase, ph...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry
2013-08-01
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| Series: | Biotechnologia Acta |
| Subjects: | |
| Online Access: | http://biotechnology.kiev.ua/images/no4_2013/mikhailopulo_4_2013.pdf |
| _version_ | 1827848703370592256 |
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| author | A. Mikhailopulo A. I. Miroshnikov |
| author_facet | A. Mikhailopulo A. I. Miroshnikov |
| author_sort | A. Mikhailopulo |
| collection | DOAJ |
| description | Some recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the mechanism of functioning of the ribokinase, phosphopentomutase, and uridine, thymidine and purine nucleoside (PNP) phosphorylases, and the role of different factors (structural, electronic, stereochemical) in the glycoside bond formation, (ii) the modern chemistries of the chemo-enzymatic syntheses of nucleosides, (iii) the transglycosylation reaction using natural and sugar modified nucleosides as donors of carbohydrate residues and heterocyclic bases as acceptors catalyzed by nucleoside phosphorylases (NP). |
| first_indexed | 2024-03-12T09:51:44Z |
| format | Article |
| id | doaj.art-e526c54e749d4e1abeda8f0a6bd103a4 |
| institution | Directory Open Access Journal |
| issn | 2410-7751 2410-776X |
| language | English |
| last_indexed | 2024-03-12T09:51:44Z |
| publishDate | 2013-08-01 |
| publisher | National Academy of Sciences of Ukraine, Palladin Institute of Biochemistry |
| record_format | Article |
| series | Biotechnologia Acta |
| spelling | doaj.art-e526c54e749d4e1abeda8f0a6bd103a42023-09-02T12:30:00ZengNational Academy of Sciences of Ukraine, Palladin Institute of BiochemistryBiotechnologia Acta2410-77512410-776X2013-08-0164637710.15407/biotech6.04.063SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDESA. Mikhailopulo0A. I. Miroshnikov1Institute of Bioorganic Chemistry of Belarus National Academy of Sciences, Minsk, BelarusShemyakin and Ovchinnikov Institute of Bioorganic Chemistry of Russian Academy of Sciences, Moscow, RussiaSome recent findings in the biotechnology of biologically important nucleosides will be discussed, viz., (i) a new strategy of the cascade one-pot transformation of D-pentoses into nucleosides based on the extension and deepening of the knowledge of the mechanism of functioning of the ribokinase, phosphopentomutase, and uridine, thymidine and purine nucleoside (PNP) phosphorylases, and the role of different factors (structural, electronic, stereochemical) in the glycoside bond formation, (ii) the modern chemistries of the chemo-enzymatic syntheses of nucleosides, (iii) the transglycosylation reaction using natural and sugar modified nucleosides as donors of carbohydrate residues and heterocyclic bases as acceptors catalyzed by nucleoside phosphorylases (NP).http://biotechnology.kiev.ua/images/no4_2013/mikhailopulo_4_2013.pdfnucleosidesbio-mimetic synthesischemo-enzymatic synthesisenzymes of nucleic acid metabolism. |
| spellingShingle | A. Mikhailopulo A. I. Miroshnikov SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES Biotechnologia Acta nucleosides bio-mimetic synthesis chemo-enzymatic synthesis enzymes of nucleic acid metabolism. |
| title | SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES |
| title_full | SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES |
| title_fullStr | SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES |
| title_full_unstemmed | SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES |
| title_short | SOME RECENT FINDINGS IN THE BIOTECHNOLOGY OF BIOLOGICALLY IMPORTANT NUCLEOSIDES |
| title_sort | some recent findings in the biotechnology of biologically important nucleosides |
| topic | nucleosides bio-mimetic synthesis chemo-enzymatic synthesis enzymes of nucleic acid metabolism. |
| url | http://biotechnology.kiev.ua/images/no4_2013/mikhailopulo_4_2013.pdf |
| work_keys_str_mv | AT amikhailopulo somerecentfindingsinthebiotechnologyofbiologicallyimportantnucleosides AT aimiroshnikov somerecentfindingsinthebiotechnologyofbiologicallyimportantnucleosides |