Holistic health record for Hidradenitis suppurativa patients
Abstract Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease with a complex etiopathogenesis whose treatment poses a challenge in the clinical practice. Here, we present a novel integrated pipeline produced by the European consortium BATMAN (Biomolecular Analysis for Tailored Medi...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2022-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-11910-5 |
| _version_ | 1811341310490050560 |
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| author | Paola Maura Tricarico Chiara Moltrasio Anton Gradišek Angelo V Marzano Vincent Flacher Wacym Boufenghour Esther von Stebut Matthias Schmuth Wolfram Jaschke Matjaž Gams Michele Boniotto Sergio Crovella |
| author_facet | Paola Maura Tricarico Chiara Moltrasio Anton Gradišek Angelo V Marzano Vincent Flacher Wacym Boufenghour Esther von Stebut Matthias Schmuth Wolfram Jaschke Matjaž Gams Michele Boniotto Sergio Crovella |
| author_sort | Paola Maura Tricarico |
| collection | DOAJ |
| description | Abstract Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease with a complex etiopathogenesis whose treatment poses a challenge in the clinical practice. Here, we present a novel integrated pipeline produced by the European consortium BATMAN (Biomolecular Analysis for Tailored Medicine in Acne iNversa) aimed at investigating the molecular pathways involved in HS by developing new diagnosis algorithms and building cellular models to pave the way for personalized treatments. The objectives of our european Consortium are the following: (1) identify genetic variants and alterations in biological pathways associated with HS susceptibility, severity and response to treatment; (2) design in vitro two-dimensional epithelial cell and tri-dimensional skin models to unravel the HS molecular mechanisms; and (3) produce holistic health records HHR to complement medical observations by developing a smartphone application to monitor patients remotely. Dermatologists, geneticists, immunologists, molecular cell biologists, and computer science experts constitute the BATMAN consortium. Using a highly integrated approach, the BATMAN international team will identify novel biomarkers for HS diagnosis and generate new biological and technological tools to be used by the clinical community to assess HS severity, choose the most suitable therapy and follow the outcome. |
| first_indexed | 2024-04-13T18:54:58Z |
| format | Article |
| id | doaj.art-e527653806ca476aa2dfc535c9b5ebd6 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-13T18:54:58Z |
| publishDate | 2022-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-e527653806ca476aa2dfc535c9b5ebd62022-12-22T02:34:18ZengNature PortfolioScientific Reports2045-23222022-05-0112111310.1038/s41598-022-11910-5Holistic health record for Hidradenitis suppurativa patientsPaola Maura Tricarico0Chiara Moltrasio1Anton Gradišek2Angelo V Marzano3Vincent Flacher4Wacym Boufenghour5Esther von Stebut6Matthias Schmuth7Wolfram Jaschke8Matjaž Gams9Michele Boniotto10Sergio Crovella11Department of Advanced Diagnostics, Institute for Maternal and Child Health - IRCCS Burlo GarofoloDermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoDepartment of Intelligent System, Jožef Stefan InstituteDermatology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore PoliclinicoLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire Et Cellulaire, University of StrasbourgLaboratory CNRS I2CT/UPR3572 Immunology, Immunopathology and Therapeutic Chemistry, Strasbourg Drug Discovery and Development Institute (IMS), Institut de Biologie Moléculaire Et Cellulaire, University of StrasbourgDepartment of Dermatology, University of CologneDepartment of Dermatology, Venereology and Allergy, Medical University of InnsbruckDepartment of Dermatology, Venereology and Allergy, Medical University of InnsbruckDepartment of Intelligent System, Jožef Stefan InstituteINSERM, IMRB, Translational Neuropsychiatry, F-94010, University Paris Est CréteilBiological Sciences Program, Department of Biological and Environmental Sciences, College of Arts and Sciences, University of QatarAbstract Hidradenitis suppurativa (HS) is a recurrent inflammatory skin disease with a complex etiopathogenesis whose treatment poses a challenge in the clinical practice. Here, we present a novel integrated pipeline produced by the European consortium BATMAN (Biomolecular Analysis for Tailored Medicine in Acne iNversa) aimed at investigating the molecular pathways involved in HS by developing new diagnosis algorithms and building cellular models to pave the way for personalized treatments. The objectives of our european Consortium are the following: (1) identify genetic variants and alterations in biological pathways associated with HS susceptibility, severity and response to treatment; (2) design in vitro two-dimensional epithelial cell and tri-dimensional skin models to unravel the HS molecular mechanisms; and (3) produce holistic health records HHR to complement medical observations by developing a smartphone application to monitor patients remotely. Dermatologists, geneticists, immunologists, molecular cell biologists, and computer science experts constitute the BATMAN consortium. Using a highly integrated approach, the BATMAN international team will identify novel biomarkers for HS diagnosis and generate new biological and technological tools to be used by the clinical community to assess HS severity, choose the most suitable therapy and follow the outcome.https://doi.org/10.1038/s41598-022-11910-5 |
| spellingShingle | Paola Maura Tricarico Chiara Moltrasio Anton Gradišek Angelo V Marzano Vincent Flacher Wacym Boufenghour Esther von Stebut Matthias Schmuth Wolfram Jaschke Matjaž Gams Michele Boniotto Sergio Crovella Holistic health record for Hidradenitis suppurativa patients Scientific Reports |
| title | Holistic health record for Hidradenitis suppurativa patients |
| title_full | Holistic health record for Hidradenitis suppurativa patients |
| title_fullStr | Holistic health record for Hidradenitis suppurativa patients |
| title_full_unstemmed | Holistic health record for Hidradenitis suppurativa patients |
| title_short | Holistic health record for Hidradenitis suppurativa patients |
| title_sort | holistic health record for hidradenitis suppurativa patients |
| url | https://doi.org/10.1038/s41598-022-11910-5 |
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